Camoutsis, CharalabosCiric, AnaGeronikaki, AthinaSokovic, MarinaΖουμπουλάκης, ΠαναγιώτηςΖερβού, ΜαρίαTokyoA series of thirteen new thiadiazole compounds were synthesized and evaluated for in vitro antifungal and antibacterial activity. All compound tested showed significant antifungal activity against all the micromycetes, compared to the commercial fungicide bifonazole. Differences in their activity depend on the substitution of different reactive groups. More specifically, best antifungal activity was shown for the synthetic analogue with methylpiperazine reactive group. Furthermore, it is apparent that different compounds reacted on different ways against bacteria. An effort was made to correlate the above mentioned differences in activity with lipophilicity studies. Furthermore, NMR and molecular modelling were used to obtain the main conformational features of a potent analogue, for future in silica studies.160-167https://hdl.handle.net/10442/125270009-2363engPharmaceutical Society Japan© PHARMACEUTICAL SOC JAPAN© PHARMACEUTICAL SOC JAPANChemical & Pharmaceutical BulletinantifungalthiadiazoleketoconazoleantibacterialChemistry, MedicinalChemistry, MultidisciplinarybifonazoleSulfonamide-1,2,4-thiadiazole Derivatives as Antifungal and Antibacterial Agents: Synthesis, Biological Evaluation, Lipophilicity, and Conformational StudiesΆρθρο σε επιστημονικό περιοδικό2010-02Δημοσίευση σε περιοδικόPublication in journalΧημείαChemical sciencesFrascati 42Φαρμακευτική χημείαMedicinal chemistryisi - Chemistry, Medicinal includes resources emphasizing the isolation and study of substances with therapeutic potential. Topics of interest are quantitative structure-function relationships, structural characterization and organic syntheses of naturally occurring compounds, and chemical and analytical techniques used in rational drug design. See also the PHARMACOLOGY & PHARMACY category.Φαρμακολογία και ΦαρμακευτικήPharmacology and Pharmacyisi - Pharmacology & Pharmacy covers resources on the discovery and testing of bioactive substances, including animal research, clinical experience, delivery systems, and dispensing of drugs. This category also includes resources on the biochemistry, metabolism, and toxic or adverse effects of drugs.Επιστημονικό άρθροScientific articleΕθνικό Ίδρυμα Ερευνών (ΕΙΕ)Greek Aggregator OpenArchives.gr | National Documentation Centre (EKT)