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Absorbed Dose Distribution in Boron Neutron Capture Therapy for the Treatment of Brain Cancer

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Hellenic Nuclear Physics Society   

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Absorbed Dose Distribution in Boron Neutron Capture Therapy for the Treatment of Brain Cancer (EN)
Pantelis, Evaggelos
Kalamara, Antigoni
Koukouletsou, Ioanna
Kalef Ezra, John
Stamatelatos, Ion
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
2024-07-31
Boron Neutron Capture Therapy (BNCT) is a promising re-emerging therapeutic approach for brain tumors, such as glioblastoma multiforme, where conventional treatments have limited efficacy. BNCT is based on neutron irradiation of tumors to selectively kill malignant cells that have accumulated boron compounds with high LET particles produced from the thermal neutron absorption reaction in 10B. Two sets of simulations were performed using the MCNP6.1 code. The first involves the study of the dose components as a function of depth in a cylindrical head phantom consisting of water. The second one deals with the estimation of macroscopic dosimetric quantities to the critical structures in the voxelized Zubal anthropomorphic head/neck phantom. Simulations were performed for different neutron energy spectra, beam radii, as well as boron concentrations in the tumor and the surrounding healthy tissues. The findings contribute to the optimized irradiation of the target in BNCT, while sparing of the patient’s surrounding healthy tissues. (EN)
cancer therapy (EN)
Monte Carlo simulations (EN)
neutron (EN)
radiation dosimetry (EN)
Annual Symposium of the Hellenic Nuclear Physics Society
English
Hellenic Nuclear Physics Society (HNPS) (EN)
2654-0088
2654-007X
Annual Symposium of the Hellenic Nuclear Physics Society; Τόμ. 30 (2024); 215-218 (EL)
HNPS Advances in Nuclear Physics; Vol. 30 (2024): HNPS2023; 215-218 (EN)
Πνευματική ιδιοκτησία (c) 2024 Ioanna Koukouletsou, John Kalef Ezra, Evaggelos Pantelis, Antigoni Kalamara, Ion Stamatelatos (EL)
http://creativecommons.org/licenses/by-nc-nd/4.0
Hellenic Nuclear Physics Society
Annual Symposium of the Hellenic Nuclear Physics Society



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