Baltas, DLahanas, MWe consider the problem of anatomy based dose optimization in brachytherapy. A calculation method for some objective functions and their derivatives is proposed which significantly reduces the number of required operations. The optimization in some cases, ignoring a preprocessing step, is independent of the number of sampling points. The idea is that some of the objectives and their derivatives used for dose optimization do not require the explicit calculation of dose values. Dose optimization with the new modified computation method for the objectives and derivatives is, depending on the number of sampling points, up to 100 times faster than the conventional method with dose calculation. (C) 2003 American Association of Physicists in Medicine.http://hdl.handle.net/123456789/1515423680094-240523759ISI:0001853791000143010.1118/1.1580483engAMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICSMedical PhysicscalculationdosimetryHumansOptimization algorithmstechniqueMaleRadiation ProtectionProstatic NeoplasmsComputer SimulationSensitivity and SpecificityDose FractionationRadiometryBrachytherapybrachytherapypriority journalRadiotherapy Planning, Computer-AssistedRadiotherapy DosageReproducibility of ResultsRisk AssessmentModels, StatisticalOrgan SpecificityarticleSample SizeAlgorithmsmathematical computingModels, Biologicalmathematical modelAre dose calculations during dose optimization in brachytherapy necessary?journalArticle2003Ραδιολογία, Πυρηνική ιατρική και ΑπεικονιστικήRadiology, Nuclear Medicine and Imagingisi - Radiology, Nuclear Medicine & Medical Imaging covers resources on radiation research in biology and biophysics. Resources in this category focus on interventional radiology, investigative radiology, neuroradiology, radiotherapy, and oncology. Nuclear Medicine resources are concerned with the diagnostic, therapeutic, and investigative use of radionuclides. Medical Imaging resources are concerned with computerized medical imaging and graphics.Δημοσίευση σε περιοδικόPublication in journalΕπιστημονικό άρθροScientific articleΕθνικό Μετσόβιο ΠολυτεχνείοGreek Aggregator OpenArchives.gr | National Documentation Centre (EKT)other