Varvarigou, TStamatakos, GMenychtas, AKaklamani, DDionysiou, DAthanaileas, TKyriazis, DUzunoglu, NIn silico (on the computer) oncology is a complex and multiscale combination of sciences and technologies that focuses on the study and modelling of biological mechanisms related to the phenomenon of cancer at all levels of biocomplexity. In silico oncology simulation models may be used for evaluating and comparing different therapeutic schemes, while at the same time considering different values of critical parameters which present substantial inter-patient variability. As the number of the involved parameters characterizing both the complex tumour biosystem and possible treatment schemes increases, the resulting exponential increase in computational requirements makes the use of a grid environment for the execution of the simulations a particularly attractive solution. In this paper, a grid-enabled simulation environment for the execution of in silico oncology radiotherapy simulations on grid infrastructures is presented and implementation details are discussed. The environment provides a web portal as the end-user interface and contains advanced features that facilitate the execution of in silico oncology simulations in grid environments. Special consideration has been given during the development of the environment in order to simplify the maintenance and extension of the application, while additional services for Quality of Service provisioning have been applied. The simulation environment has been employed in order to perform several scenarios of glioblastoma multiforme radiotherapy simulations on the Enabling Grids for E-sciencE (EGEE) grid infrastructure. Indicative simulation results, as well as statistics regarding execution times on the grid, are presented. © The Author(s) 2010.http://hdl.handle.net/123456789/2116389391010.1177/0037549710375437ISI:0002955974000040037-54978710engSAGE PUBLICATIONS LTDSimulationExponential increaseParameters characterizingIn silico oncologyGrid-enabled simulationsQuality of service provisioningQuality of serviceparameter sweep simulationsGrid technologiesOncologyComputational requirementsMultiscalesExperimentsGrid infrastructuresVirtual realityGrid computingClinical trialSimulation modelMedical applicationsExecution timeEnd-user interfacesGrid environmentsCircuit simulationCritical parameterBiocomplexityRadiotherapyGlioblastoma multiformevirtual clinical trialGrid portalsgrid portalSimulation environmentBiological mechanismsIn-silicoBio systemsRadiation oncologyWeb portalUser interfacese-ScienceAttractive solutionsExploiting grid technologies for the simulation of clinical trials: The paradigm of in silico radiation oncologyjournalArticle2011Δημοσίευση σε περιοδικόPublication in journalΛογισμικό (software)Softwareisi - Computer Science, Software Engineering includes resources that are concerned with the programs, routines, and symbolic languages that control the functioning of the hardware and direct its operation. Also covered in this category are computer graphics, digital signal processing, and programming languages.Επιστημονικό άρθροScientific articleΕθνικό Μετσόβιο ΠολυτεχνείοGreek Aggregator OpenArchives.gr | National Documentation Centre (EKT)other