Tsiakalos, AKaltsas, GThomas, DAlexandraki, KMoisidis, ASyriou, VBackground: Antithyroid drugs have been used for more than 50 years for the management of hyperthyroidism. Most patients tolerate treatment well but some may develop life threatening side effects such as agranulocytosis and aplastic anemia (AA). We review all cases of antithyroid drug induced AA and describe, as illustrative cases, two women with Graves' disease who developed AA after 8 and 24 weeks of carbimazole (CBM) and methimazole (MMI) treatment respectively. Patient findings and summary: To date, at least 34 cases of aplastic anemia (AA) due to antithyroid drugs [(1 with CMZ, 31 with MMI, and 2 with propylthiouracil (PTU)] have been published, not including the two patients described here. In addition, at least another 14 patients in whom AA developed after treatment with antithyroid drugs (11 with CMZ, and 3 with MMI) have been reported in Yellow Card Scheme data analysis. Patients with AA usually exhibit sudden onset of symptoms after a relative short time of exposure to the drugs, and all have concomitant agranulocytosis. Most have a rapid recovery following discontinuation of the drug and supportive treatment. Although only two antithyroid drug induced AA deaths have been published, the mortality rate was higher in the Yellow Card Scheme data analysis. Conclusions: Aplastic anemia associated with antithyroid drug treatment is rarer than antithyroid drug associated agranulocytosis. The prognosis of patients with antithyroid drug induced AA is good overall, but may not be as favorable as that of antithyroid drug induced isolated agranulocytosis.http://hdl.handle.net/123456789/28397ISI:00026024780000310481050-725618104310engMARY ANN LIEBERT INCTHYROIDRECOVERYPROPYLTHIOURACILTHERAPYCOLONY-STIMULATING FACTORMETHIMAZOLE-INDUCED AGRANULOCYTOSISCSFGRAVES-DISEASEBONE-MARROW APLASIAPLASMACYTOSISAntithyroid Drug-Induced Aplastic AnemiajournalArticle2008Δημοσίευση σε περιοδικόPublication in journalΕνδοκρινολογία, Διαβήτης και ΜεταβολισμόςEndocrinology, Diabetes and Metabolismisi - Endocrinology & Metabolism includes resources focused on endocrine glands; the regulation of cell, organ, and system function by the action of secreted hormones; the generation and chemical/biological properties of these substances; and the pathogenesis and treatment of disorders associated with either source or target organs. Specific areas covered include neuroendocrinology, reproductive endocrinology, pancreatic hormones and diabetes, regulation of bone formation and loss, and control of growth.Επιστημονικό άρθροScientific articleΕθνικό Μετσόβιο ΠολυτεχνείοGreek Aggregator OpenArchives.gr | National Documentation Centre (EKT)other