Mild and Rapid Method for the Generation of ortho-(Naphtho)quinone Methide Intermediates

 
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2012 (EN)
Mild and Rapid Method for the Generation of ortho-(Naphtho)quinone Methide Intermediates (EN)

Shaikh, A. K. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Shaikh, A. K. (EN)

A new mild method has been devised for generating o-(naphtho)quinone methides via fluoride-induced desilylation of silyl derivatives of o-hydroxybenzyl(or 1-naphthylmethyl) nitrate. The reactive o-(naphtho)quinone methide intermediates were trapped by C, O, N, and S nucleophiles and underwent "inverse electron-demand" hetero-Diels-Alder reaction with dienophiles to give stable adducts. The method has useful potential application in natural product synthesis and drug research. (EN)

o-quinone methides (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Org Lett (EN)

English

2012

<Go to ISI>://000299238600041

American Chemical Society (EN)



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