Multinuclear 1D and 2D NMR investigations on the interaction between the pyrimidic nucleotides 5 '-CMP, 5 '-dCMP, and 5 '-UMP and diethyltin dichloride in aqueous medium

 
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Multinuclear 1D and 2D NMR investigations on the interaction between the pyrimidic nucleotides 5 '-CMP, 5 '-dCMP, and 5 '-UMP and diethyltin dichloride in aqueous medium (EN)

Ghys, L. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Ghys, L. (EN)

The interactions between diethyltin dichloride and 5'-CMP, 5'-dCMP, and 5'-UMP in aqueous solution were investigated by multinuclear 1D and 2D NMR techniques including Sn-119, N-15 and P-31 nuclei. These studies were combined with electrospray mass spectrometry, infrared spectroscopy, solid state C-13, P-31 and Sn-117 CP-MAS NMRI and elemental analysis. As demonstrated by P-31-H-1 HOESY spectroscopy the diethyltin moiety interacts with the phosphate group of the pyrimidic mononucleotides in the pH range 0.5-3.5. Compound 8 (X = Cl), the solid isolated in this pH range from 5'-CMP, contains two tin atoms bridged by one oxygen and one chlorine atom, each tin atom being linked to the phosphate group of a nucleotide moiety. For 5'-UMP the solid isolated (12) has a dimeric structure with two different tin atoms; it can be formed by dimerization of compound it with the elimination of two water molecules. As demonstrated by H-1-Sn-119 HMQC correlation NMR data and the (2)J(Sn-119-O-Sn-117) coupling constant of 156 Hz, the diethyltin moiety reacts with the O(2') and O(3') oxygen atoms of the nucleotides to form a dimeric diethyldioxastannolane at pH > 9.0. Between pH 5.0 and 9.0, no evidence for any interaction between the diethyltin moiety and the nucleotides was found. (EN)

tin (EN)


European Journal of Inorganic Chemistry (EN)

English

2000


Wiley-VCH Verlag (EN)



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