Perturbation Theory in the Catalytic Rate Constant of the Henri-Michaelis-Menten Enzymatic Reaction

 
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2012 (EN)
Perturbation Theory in the Catalytic Rate Constant of the Henri-Michaelis-Menten Enzymatic Reaction (EN)

Bakalis, E. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Bakalis, E. (EN)

The Henry-Michaelis-Menten (HMM) mechanism of enzymatic reaction is studied by means of perturbation theory in the reaction rate constant k (2) of product formation. We present analytical solutions that provide the concentrations of the enzyme (E), the substrate (S), as well as those of the enzyme-substrate complex (C), and the product (P) as functions of time. For k (2) small compared to k (-1), we properly describe the entire enzymatic activity from the beginning of the reaction up to longer times without imposing extra conditions on the initial concentrations E (o) and S (o) , which can be comparable or much different. (EN)

enzyme catalyzed reactions (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Bulletin of Mathematical Biology (EN)

English

2012

<Go to ISI>://000310316100001

Springer Verlag (Germany) (EN)



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