Φλεγμονώδης πάθηση των εντέρων

 
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PhD thesis (EN)

1995 (EN)
Φλεγμονώδης πάθηση των εντέρων (EL)

Νταλέκος, Γεώργιος Ν. (EL)

Τσιάνος, Επαμεινώνδας (EL)
Νταλέκος, Γεώργιος Ν. (EL)
Πανεπιστήμιο Ιωαννίνων Σχολή Ιατρικής Τμήμα Ιατρικής (EL)
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THE PRESENT STUDY HAD TWO AIMS. FIRST, TO INVESTIGATE FOR A POSSIBLE AUTOIMMUNERESPONSE IN PATIENTS WITH ULCERATIVE COLITIS AS WELL AS, THE PRESENCE OF CELLULAR IMMUNE ACTIVATION BY DETECTING THE SOLUBLE INTERLEUKIN-2 RECEPTORS (SIL-2RS) LEVELS. SECOND, TO STUDY THE PRESENCE OF SEVERAL CYTOKINES IN THESE PATIENTS. IN THE FIRST PART, IT WAS FOUND THAT ULCERATIVE COLITIS IS ACCOMPANIEDBY AN AUTOIMMUNE RESPONSE (76.3% AUTOANTIBODIES OF AT LEAST ONE SPECIFICITY)AND INCREASED CELLULAR IMMUNE ACTIVATION (HIGH SIL-2R CONCENTRATIONS). THESEFINDINGS WERE CONFIRMED IN PAIRED SERUM SAMPLES TAKEN FROM 10 PATIENTS DURING ACTIVE DISEASE AND AFTER UNDERGOING A CLINICAL REMISSION AND RELATED WITH THE ACTIVITY OF THE DISEASE. IN THE SECOND PART, IT WAS FOUND THAT ULCERATIVE COLITIS IS ALSO ACCOMPANIED BY HIGH INTERLEUKIN-6 (IL-6) LEVELS WHICH CORRELATED WITH THE ACTIVITY OF THE DISEASE. THESE MARKERS (SIL-2RS, IL-6) APPEAR TO BE THE MOST USEFUL LABORATORY INDICATORS FOR ASSESSING THE ACTIVITY OF ULCERATIVE COLITIS. NO OTHER CYTOKINE HAS BEEN DETECTED IN THE SYSTEMIC CIRCULATIONOF THE PATIENTS WITH ULCERATIVE COLITIS. (EN)

doctoralThesis

Αντισώματα κατά κυτταροπλάσματος ουδετεροφίλων (EL)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Greek

1995


Πανεπιστήμιο Ιωαννίνων Σχολή Ιατρικής Τμήμα Ιατρικής (EL)



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