Synthesis of (E)-3-(1H-pyrrol-3-yl)prop-2-ene derivatives using organophosphorous reagents

 
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2006 (EN)
Synthesis of (E)-3-(1H-pyrrol-3-yl)prop-2-ene derivatives using organophosphorous reagents (EN)

Karousis, N. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Karousis, N. (EN)

The synthesis of (E)-3-[1-(toluene-4-sulfonyl)-1H-pyrrol-3-yl]prop-2-ene derivatives from 1-(toluene-4-sulfonyl)-1H-pyrrole-3-carbaldehyde by the Horner-Wadsworth-Emmons (HWE) reaction, is described. However, the HWE reaction with diethyl methoxymethylphosphonate and diethyl (2-methoxy-ethoxy)methylphosphonate gave a different product, namely, diethyl {1-methoxy(or methoxyethoxy)-2-[1-(toluene-4-sulfonyl)1H-pyrrol-3-yl]vinyl}phosphonates, respectively. (E)-3-[1-(Toluene-4-sulfonyl)-1H-pyrrol-3-yl]prop-2-enes were easily hydrolysed to (E)-3-(1H-pyrrot-3-yl)prop-2-enes, two of which are natural products. (EN)

pyrroles (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Synthesis-Stuttgart (EN)

English

2006

<Go to ISI>://000237406200019

Thieme Publishing (EN)



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