Synthesis of a novel triphenyltin(IV) derivative of 2-mercaptonicotinic acid with strong cytotoxicity in vitro

 
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2003 (EN)
Synthesis of a novel triphenyltin(IV) derivative of 2-mercaptonicotinic acid with strong cytotoxicity in vitro (EN)

Xanthopoulou, M. N. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Xanthopoulou, M. N. (EN)

A novel triphenyltin(IV) derivative of 2-mercaptonicotinic acid (Hzmna) of formula {[(C6Hs)3Sn]E(mna)"™[(CH3)2CO]} (1) has been synthesized and characterized by elemental analysis and 13C-NMR, and FT-IR spectroscopic techniques. The crystal structure of complex (1) has been determined by single crystal X-ray diffraction analysis at 173(1) K. Compound (1) contains two triphenyltin moieties linked by a doubly de-protonated 2,mercaptonicotinic acid (HEmna). It is an example of a pentacoordinated Ph3SnXY system with an axial-equatorial arrangement of the phenyl groups at Sn(1). Compound (1), exhibits potent, in vitro, cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, polycyclic aromatic hydrocarbons (PAH, benzo[a]pyrene) carcinogenesis. (EN)

triphenyltin(IV) compound, S ligands-heterocyclic thioamides, mercaptonicotinic acid, crystal structures (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Bioinorganic Chemistry & Applications (EN)

English

2003




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