Synthesis of Thieno[2,3-D]Pyrimidines from 4,6-Dichloropyrimidine-5-Carbaldehydes

 
This item is provided by the institution :
University of Ioannina
Repository :
Repository of UOI Olympias
see the original item page
in the repository's web site and access all digital files if the item*
share



1993 (EN)
Synthesis of Thieno[2,3-D]Pyrimidines from 4,6-Dichloropyrimidine-5-Carbaldehydes (EN)

Clark, J. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Clark, J. (EN)

Several thieno[2,3-d]pyrimidines have been prepared by intramolecular cyclisation of 6-(substituted methylthio)-5-pyrimidinecarbaldehyde and carbonitrile intermediates derived from 6-chloropyrimidine-5-carbaldehydes and 5-carbonitriles and methyl thioglycolate or 5-formylpyrimidine-4-(3H)-thiones and appropriate alpha-halogeno compounds. Thienopyrimidines 18 and 5c were nitrated to the corresponding nitro compounds 23 and 24. Hydrolysis at position 4 of compound 18 also occurred during nitration. The ester 5g was hydrolysed in base to the acid 25. (EN)

pyrimidine-derivatives (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Journal of Heterocyclic Chemistry (EN)

English

1993

<Go to ISI>://A1993MD59700039

Wiley-Blackwell (EN)



*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)