Silver(I) bromide reacts with 2-mercapto-3,4,5,6-tetrahydropyrimidine (StpmH(2), C4H8N2S) in DMSO with an excess of triethylamine to give a water-insoluble complex of formula [Ag-6(mu(2)-Br)(6)(mu(2)-StpmH(2))(4)(mu(3)-StpmH(2))(2)](n) (1), while the reaction of silver(I) nitrate with StpmH(2) under the same conditions gives a water-insoluble complex of formula [{Ag-4(mu(2)-StpmH(2))(6)}(NO3)(4)](n) (2). The products were characterized by elemental analyses, and FT-IR far-IR, UV/Vis, H-1 and C-13 NMR spectroscopy. Crystal structures of complexes 1 and 2 were determined by X-ray diffraction. Complex 1, C24H48Ag6N12S6, crystallizes in the triclinic system space group P (1) over bar, a = 8.041(1) Angstrom, b = 12.838(4) Angstrom, c = 13.281(2) Angstrom, alpha = 68.40(1)degrees, = 72.97(1)degrees, gamma = 87.80(2), Z = 2, forming a one-dimensional infinite ribbon structure by strong interatomic interactions of two mu(2)-Br bonds with Ag(1). Complex 2, C24H48Ag4N16O12S6, crystallizes in the orthorhombic system, space group Cmc2(1), and a = 32.148(3) Angstrom, b = 9.461(2) Angstrom, c = 7.234(1) Angstrom, alpha = beta = gamma = 90degrees, Z = 8, forming infinite Ag-S-Ag chains which are bridged to each other by a sulfur atom of mu(2)-StpmH(2) ligands. Complexes 1 and 2 were studied for their cytostatic activity against murine leukemia (L1210) and human T-lymphocyte (Molt4/C8 and CEM) cells and for their antiviral activity against a wide variety of viruses. They are markedly cytostatic at 50% inhibitory concentration (IC50) values ranging from 3 to 17 mug/mL. None of the compounds showed appreciable antiviral activity at subtoxic concentrations. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
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