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Report of novel chromosomal abnormalities in a series of 130 chronic lymphocytic leukemia patients studied by classic cytogenetic analysis

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Report of novel chromosomal abnormalities in a series of 130 chronic lymphocytic leukemia patients studied by classic cytogenetic analysis (EN)
Vadikolia, C. (EN)
Asteriou, O. (EN)
Anagnostopoulos, A. (EN)
Stamatopoulos, K. (EN)
Fassas, A. (EN)
Athanasiadou, A. (EN)
Tsezou, A. (EN)
journalArticle (EN)
2006
2015-11-23T10:23:11Z
One-hundred-and-thirty typical, unselected CLL cases were studied by conventional cytogenetic analysis. Seventy-three patients (56.2%) had normal karyotype ('normal sub-group'), while 57/130 patients (43.8%) had abnormal karyotype. Twenty-two of 57 patients (38.6%) carried more than one abnormality. Six novel chromosomal abnormalities were detected in five patients: (i) t(3; 13)(q14; q34); (ii) t(Y; 11)(q12; q23), del( 13)(q12q14); (iii) dic(3; 11)(p21; q23); (iv) t( 3; 5)(q29; q23); ( v) t( 3; 22) ( p21; q13); and ( vi) t( 1; 13)(p12; q12). Three of five patients carrying novel translocations had progressive disease. The true biological and clinical significance of novel chromosomal abnormalities remains to be determined. (EN)
CLL (EN)
translocation (EN)
Hematology (EN)
TRANSLOCATIONS (EN)
FISH (EN)
GENOMIC ABERRATIONS (EN)
Oncology (EN)
immunoglobulin genes (EN)
University of Thessaly
University of Thessaly Institutional Repositoty
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