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Report of two novel chromosomal translocations in chronic lymphocytic leukemia

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Report of two novel chromosomal translocations in chronic lymphocytic leukemia (EN)
Anagnostopoulos, A. (EN)
Stamatopoulos, K. (EN)
Tsompanakou, A. (EN)
Foutsitsakis, D. (EN)
Fassas, A. (EN)
Athanasiadou, A. (EN)
Tsezou, A. (EN)
journalArticle (EN)
2005
2015-11-23T10:23:11Z
Two novel chromosomal translocations were identified in 2 patients with chronic lymphocytic leukemia (CLL). Case 1: 60 year-old male, stage Rai 0/Binet A, with mutated immunoglobulin heavy (IgH) and lambda (Iglambda) light chain genes; karyotype: 46, XY, t(9;12)(q12;p11) [3]/ 46, XY [22]. Case 2: 56 year-old male, stage Rai 2/Binet B, with mutated IgH and unmutated Iglambda genes; karyotype: 46, XY, add(10)(q26), t(13;18)(q14;q21) [8]/ 46, XY [27]. Although both translocations are novel, the involved breakpoints (especially 13q14 and 18q21) have been reported to participate in various aberrations in CLL patients. Aberrations affecting bands 9q12 and 12p11, as in case 1, are generally rare. (EN)
Hematology (EN)
GENES (EN)
GENOMIC ABERRATIONS (EN)
Oncology (EN)
University of Thessaly
University of Thessaly Institutional Repositoty
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