Potential effect of Nigella sativa against Diethylnitrosamine-induced hepatocarcinogenesis in rats

 
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Journal of the Hellenic Veterinary Medical Society  | ΕΚΤ eJournals
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Τμήμα περιοδικού (EL)
Επιστημονικό άρθρο (EL)
2017 (EL)
Potential effect of Nigella sativa against Diethylnitrosamine-induced hepatocarcinogenesis in rats (EN)
BRELLOU (Γ. ΜΠΡΕΛΛΟΥ), G.
LOUKOPOULOS (Π. ΛΟΥΚΟΠΟΥΛΟΣ), P.
GAMEEL, A. A.
VLEMMAS (Ι. ΒΛΕΜΜΑΣ), I.
AHMED, S. E.
Objective of the investigation was the study of potential protective effects of the watery extract of Nigella sativa against diethylnitrosamine induced hepatocarcinogenesis in rats. N. sativa was administered to rats for protection against diethylnitrosamine-induced hepatocarcinogenesis. It was administered prior to, simultaneously with or after injection of diethylnitrosamine. Five groups of Wister rats were used. Group A was administered diethylnitrosamine and N. sativa simultaneously, group B was administered only diethylnitrosamine and group C received only N. sativa. These three groups were maintained for up to eight weeks. Group D received N. sativa six weeks after administration ofdiethylnitrosamine,while group E (“protective group”) received N. sativa on day 1 and diethylnitrosamine six weeks later. These two groups were maintained for up to 12 weeks. All rats were subjected to partial hepatectomy to enhance carcinogenesis. P-isoform of glutathione s transferase (GST-P) was detected in the cytoplasm and nuclei of hepatocytes. The number of GST-P positive foci was significantly smaller in test groups (A, D, E), particularly in groups A and E, when compared with to those in group B, indicating that N. sativa has protective effects against diethylnitrosamine induced liver cancer in rats, even in the very early stages of hepatocarcinogenesis. (EN)
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
diethylnitrosamine (EN)
GST-P (EN)
Nigella sativa (EN)
hepatocarcinogenesis (EN)
Ελληνική Κτηνιατρική Εταιρεία
Journal of the Hellenic Veterinary Medical Society
Research Articles
Journal of the Hellenic Veterinary Medical Society
Αγγλική γλώσσα
2017-12-20
https://ejournals.epublishing.ekt.gr/index.php/jhvms/article/view/15511
Hellenic Veterinary Medical Society / Ελληνική Κτηνιατρική Εταιρεία (EN)
1792-2720
2585-3724
Περιοδικό της Ελληνικής Κτηνιατρικής Εταιρείας; Τόμ. 65 Αρ. 1 (2014); 35-42 (EL)
Journal of the Hellenic Veterinary Medical Society; Vol. 65 No. 1 (2014); 35-42 (EN)
Copyright (c) 2017 S. E. AHMED, G. BRELLOU (Γ. ΜΠΡΕΛΛΟΥ), A. A. GAMEEL, P. LOUKOPOULOS (Π. ΛΟΥΚΟΠΟΥΛΟΣ), I. VLEMMAS (Ι. ΒΛΕΜΜΑΣ) (EN)



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