Transcriptional regulation of endothelin-1 expression by advanced glycation end-products in human aortic endothelium is mediated via NF-kappaΒ and AP-1

Kandaraki, Eleni A.

Gargalionis, Antonios N.

Diamanti-Kandarakis, Evanthia

Adamopoulos, Christos

Piperi, Christina

Dalagiorgou, Georgia

Papavassiliou, Athanasios G.

Advanced Glycation End-products (AGEs) are produced by the non-enzymatic glycation of proteins, lipids and nucleic acids, resulting in an overload of highly reactive molecules of endogenous or exogenous (dietary) origin. Increased AGE levels in circulation and concomitant elevated tissue deposition have been associated with diabetic complications, atheromatosis, ageing and more recently with polycystic ovary syndrome pathogenesis. Interaction of AGEs with their receptor RAGE (Receptor for AGEs) activates intracellular signaling pathways which induce targeted gene expression in endothelium including upregulation of cell adhesion molecules and endothelin-1 (ET-1), implicated in vascular injury and endothelial dysfunction. The purpose of this study is to explore the molecular mechanism of AGE-induced regulation of ET-1 gene/protein expression in human endothelial cells and investigate its functional relevance in normal rat vascular endothelium.

Text (Conference or workshop item (Poster))

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βιοχημεία

ιατρική

κυτταρολογία

Επιχειρησιακό Πρόγραμμα "Εκπαίδευση και Δια Βίου Μάθηση", Υπουργείο Εκπαίδευσης και Δια Βίου Μάθησης

Ψηφιακή Βιβλιοθήκη- Επιχειρησιακό Πρόγραμμα Εκπαίδευση και Δια Βίου Μάθηση

Αγγλική γλώσσα

2012-06-23

http://repository.edulll.gr/3295

http://hdl.handle.net/10795/3295

The Endocrine Society’s 94th Annual Meeting & Expo, Houston, USA 23-26/06/2012