Differential proteomic analysis of the reactivated p53 via Nutlin-3a, in 3 different types of human lymphomas

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Differential proteomic analysis of the reactivated p53 via Nutlin-3a, in 3 different types of human lymphomas

Aivaliotis, Michalis
Drakos, Elias
Psatha, Konstantina
Rassidakis, George Z.

Text

2011-10


Purpose: The identification and quantification of protein expression levels of nutlin-3A-induced p53 stabilization and activation in human lymphoma. Methods: The Isotope Coded Protein Label (ICPL) technique was followed by nano-Liquid Chromatography coupled on-line with Mass Spectrometry (nLC-MS/MS). Results: Reliable identification & differential quantitative determination of human lymphoma proteome profile, revealing alterations in the HSPs relative expression levels.


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