Patients with established gastro-esophageal reflux disease might benefit from Helicobacter pylori eradication

Patients with established gastro-esophageal reflux disease might benefit from Helicobacter pylori eradication (EN)

Zezos, Petros

Moschos, John M.

Kouklakis, George

Chatzopoulos, Dimitrios

Zavos, Christos

Kountouras, Jannis

Pitiakoudis, Michael

Vradelis, Stergios

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

2014-09-30

Background The aim of this study was to investigate the effect of Helicobacter pylori (H. pylori) eradication in selected H. pylori-positive patients with a primary diagnosis of gastro-esophageal reflux disease (GERD) by using the 3-h postprandial esophageal pH monitoring.Methods We recruited patients with erosive esophagitis at endoscopy and H. pylori infection at histology, successfully cured following eradication therapy; the selected H. pylori-positive patients had weekly reflux symptoms for at least six months and endoscopically established Grade A or B esophagitis. Twenty-nine eligible patients were initially subjected to esophageal manometry and ambulatory 3-h postprandial esophageal pH monitoring. All patients received H. pylori triple eradication therapy accompanied by successful H. pylori eradication. After successful eradication of H. pylori (confirmed by 13C urea breath test), a second manometry and 3-h postprandial esophageal pH monitoring were introduced to assess the results of eradication therapy, after a 3-month post-treatment period.Results All 29 selected H. pylori-positive patients became negative due to successful H. pylori eradication, evaluated by 13C urea breath test after a 4-week post-treatment period. Post-eradication, 62.1% patients showed similar manometric pattern at baseline; 17.2% showed improvement; 17.2% normalization; and 3.4% deterioration of the manometric patterns. The DeMeester symptom scoring in the 3-h postprandial ambulatory esophageal pH monitoring was improved aft r eradication of H. pylori (median 47.47 vs. 22.00, Wilcoxon's singed rank; P=0.016). On comparing the pH monitoring studies for each patient at baseline and post-eradication period, 82.8% patients showed improvement and 17.2% deterioration of the DeMeester score.Conclusion By using 3-h postprandial esophageal pH monitoring, this study showed, for the first time, that H. pylori eradication may positively infl ence GERD symptoms. Large-scale controlled relative studies are warranted to confi m these findings.Keywords Helicobacter pylori, gastro-esophageal reflux disease, esophageal pH monitoring, DeMeester symptom scoringAnn Gastroenterol 2014; 27 (4): 352-356 (EN)

Αγγλική γλώσσα

Hellenic Society of Gastroenterology (EN)

1792-7463

1108-7471

Annals of Gastroenterology; Volume 27, No 4 (2014); 352 (EN)

Ελληνική Γαστροεντερολογική Εταιρία

Annals of Gastroenterology

Original Articles