1. Αρχική σελίδα
  2. Αναζήτηση

Unilateral versus bilateral hilar stents for the treatment of cholangiocarcinoma: a multicenter international study

Το τεκμήριο παρέχεται από τον φορέα :
Hellenic Society of Gastroenterology   

Αποθετήριο :
Annals of Gastroenterology   

δείτε την πρωτότυπη σελίδα τεκμηρίου
στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*



Unilateral versus bilateral hilar stents for the treatment of cholangiocarcinoma: a multicenter international study (EN)
Lam, Robert
Papachristou, Georgios
Staub, Judith
Kowalski, Thomas
Adler, Douglas G.
Greene, Tom
Iqbal, Usama
Mumtaz, Tayebah
Herrick, Jennifer
Siddiqui, Ali
Pleskow, Douglas
Yasuda, Ichiro
Parikh, Meet
Sharaiha, Reem
Thomas, Samuel
Murphy, Megan
Noor, Arish
Loren, David
Haseeb, Abdul
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
2020-03-08
Background Endoscopic placement of hilar stents is an accepted palliative therapy for patients with advanced, unresectable cholangiocarcinoma. However, whether unilateral versus bilateral stent placement provides optimal relief continues to be a subject of debate. The aim of this study was to compare the technical and clinical outcomes in patients with inoperable cholangiocarcinoma who received unilateral or bilateral self-expanding metal stents (SEMS). Methods We conducted a multicenter, international retrospective study of 187 patients with cholangiocarcinoma who received unilateral or bilateral SEMS. Outcomes included, but were not limited to, technical success, clinical success, adverse events, stent occlusion, and survival time. Results were further stratified based on the Bismuth classification. Results Fifty patients received unilateral stents and 137 patients received bilateral stents. All patients achieved technical success. The clinical success rates were 86% for unilateral stents and 82.5% for bilateral stents (P>0.99). Clinical success was not statistically different for either group when stratified by the Bismuth classification (P=0.62 and P=0.72 respectively). There were significantly more adverse events in the bilateral stents group (11.7% vs. 0%, P=0.007). There was no greater risk of stent occlusion when bilateral stents were used (unadjusted P=0.71, adjusted P=0.81). There was a greater risk of death for patients who received bilateral SEMS (hazard ratio 1.78, 95% confidence interval 1.09-2.89; P=0.02). Conclusions Unilateral and bilateral drainage had similar technical and clinical success rates. However, bilateral stents had a higher risk of death and more adverse events. Therefore, unilateral SEMS placement is sufficient for relief of biliary obstruction secondary to cholangiocarcinoma. Keywords Cholangiocarcinoma, self-expanding metal stent, hilar, unilateral, bilateral Ann Gastroenterol 2020; 33 (2): 202-209 (EN)
Αγγλική γλώσσα
Hellenic Society of Gastroenterology (EN)
1792-7463
1108-7471
Annals of Gastroenterology; Volume 33, No 2 (2020) (EN)
Hellenic Society of Gastroenterology
Annals of Gastroenterology
Original Articles



*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.