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WATS3D versus forceps biopsy in screening for Barrett’s esophagus: experience in community endoscopy centers

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Ελληνική Γαστροεντερολογική Εταιρία   

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Annals of Gastroenterology   

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WATS3D versus forceps biopsy in screening for Barrett’s esophagus: experience in community endoscopy centers (EN)
Tofteland, Nathan
Wuthnow, Chelsea
Kilgore, William
Salyers, William
Hyder, Jeffrey
Hussein Agha, Yasmine
Taleb, Ali
Srinivasan, Sachin
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
2021-03-05
Background Barrett’s esophagus (BE) is a premalignant condition diagnosed using systematic 4-quadrant forceps biopsies (FB) during endoscopy. This method is fraught with errors due to the randomness of sampling and variability among operators. Wide-area transepithelial sampling with 3-dimensional computer-assisted analysis (WATS3D) is an emerging technique used to collect esophageal samples. The aim of this study was to evaluate WATS3D as a diagnostic tool for detecting BE in addition to FB, compared to FB alone. Methods A retrospective observational cohort study was conducted and included patients who underwent screening for BE with WATS3D and FB between January 2015 and January 2019 across 3 endoscopy centers in Wichita, Kansas. The FB specimens were reviewed by community pathologists, while the WATS3D samples were sent to CDX technology labs, NY. Results A total of 108 patients were screened for BE using both modalities concurrently. FB and WATS3D detected 62 (57.4%) and 83 (76%) cases of BE, respectively. The absolute difference of 21 cases (18.6%) of BE was attributed to the addition of WATS3D. The number needed to test with WATS3D was 5. We divided the sample into 4 groups to compare the agreement across all groups: (FB–; WATS3D+), (FB–; WATS3D–), (FB+; WATS3D+), and (FB+ and WATS3D–). Overall agreement by kappa statistic was 0.74. Conclusion WATS3D identified 21 cases of BE missed by FB. Using WATS3D in addition to FB increased the yield of BE during surveillance endoscopy, with no increase in complications. Keywords Barrett’s esophagus, biopsy, cytodiagnosis, endoscopy, screening Ann Gastroenterol 2021; 34 (2): 164-168 (EN)
Αγγλική γλώσσα
Hellenic Society of Gastroenterology (EN)
1792-7463
1108-7471
Annals of Gastroenterology; Volume 34, No 2 (2021); 164 (EN)
Copyright (c) 2021 Annals of Gastroenterology (EN)
Ελληνική Γαστροεντερολογική Εταιρία
Annals of Gastroenterology
Original Articles



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