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Gastrointestinal cancer incidence after lung transplantation in sarcoidosis patients

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Ελληνική Γαστροεντερολογική Εταιρία   

Αποθετήριο :
Annals of Gastroenterology   

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Gastrointestinal cancer incidence after lung transplantation in sarcoidosis patients (EN)
Sanders, Tierra
Obi, Ogugua N.
Ali, Hassam
Adler, Douglas G.
Saeed, Graham
Oghoghorie, Stanley
Tumin, Dmitry
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
2025-01-14
Background The risk of gastrointestinal (GI) cancer after lung transplantation (LTx) in sarcoidosis patients is not well defined. Given the cancer risks linked to sarcoidosis and organ transplantation, this study investigated the incidence of GI de novo malignancies (DNM), comparing LTx recipients with sarcoidosis or idiopathic pulmonary fibrosis (IPF). Methods We analyzed data from the United Network for Organ Sharing registry, including adults with sarcoidosis or IPF who underwent LTx between May 2005 and December 2018. The primary outcome was the incidence of GI DNM by March 2023. Results Of 7996 lung transplant recipients, 108 (1.35%) developed GI malignancies posttransplantation. Among these, 662 patients (9%) had sarcoidosis and 7334 (91%) had IPF. Sarcoidosis patients showed a non-significant trend toward a higher risk of GI malignancies compared to those with IPF (subhazard ratio 1.72, 95% confidence interval 0.90-3.29; P=0.099), with no observed difference in the risk of non-GI cancers. Conclusions The overall incidence of GI DNM following LTx is low, and sarcoidosis does not appear to increase the risk of GI cancers compared to IPF. This finding suggests that enhanced GI cancer screening beyond standard guidelines may not be warranted in this population, allowing for targeted surveillance of more prevalent malignancies in sarcoidosis patients post-LTx. Keywords Gastrointestinal cancer, de novo malignancy, idiopathic pulmonary fibrosis, immunosuppression, lung transplantation Ann Gastroenterol 2025; 38 (1): 80-84 (EN)
Αγγλική γλώσσα
Hellenic Society of Gastroenterology (EN)
1792-7463
1108-7471
Annals of Gastroenterology; Volume 38, No 1 (2025); 80 (EN)
Copyright (c) 2025 Annals of Gastroenterology (EN)
Ελληνική Γαστροεντερολογική Εταιρία
Annals of Gastroenterology
Original Articles



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