Metabolic and cardiovascular complications in the liver transplant recipient
De Luca, Laura; Sheila Sherlock Liver Centre, Royal Free Hospital and UCL Institute of Liver and Digestive Health
Tsochatzis, Emmanuel A.
Metabolic syndrome (MS) is an established risk factor for atherosclerosis and cardiovascular disease that affects 20-30% of the adult population in the western world, correlating with increased incidence of cardiovascular disease. Survival following liver transplantation (LT) has been steadily improving over the last 2 decades, with graft loss becoming a relatively rare cause of morbidity and mortality post LT. The improvement in short-term survival following LT has resulted in an increased incidence of metabolic and cardiovascular complications, which affect the mid- and long term survival. Patients following LT typically gain weight and might develop diabetes, hypertension and dyslipidemia as a consequence of their immunosuppressive therapy and their lifestyle. In this paper we review the prevalence of metabolic and cardiovascular complications following LT, their impact on post-transplant morbidity and mortality and their optimal management.Keywords Liver transplantation, metabolic syndrome, cardiovascular disease, epidemiology, risk factors, morbidity, mortality, NAFLD, NASH, hypertension, obesity, dyslipidemia, diabetes mellitusAnn Gastroenterol 2015; 28 (2): 182-192