Somatostatin receptor scintigraphy with In-111 octreotide in the detection of gastroenteropancreatic carcinoids and their metastases

 
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Annals of Gastroenterology
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Somatostatin receptor scintigraphy with In-111 octreotide in the detection of gastroenteropancreatic carcinoids and their metastases (EN)

E. Paraskevas, E. Fotopoulou, N. Apostolikas,
D. Xinopoulos, K. Tsamakidis, E. Andriotis,, D. Dimitroulopoulos, A. Zisimopoulos,

SUMMARY Background: Carcinoid tumours are a very rare malignancy most frequently arising in the gastrointestinal tract. The method of choice for detection of these tumours is somatostatin receptors scintigraphy (SRS). The aim of the present study was to evaluate the diagnostic sensitivity and accuracy of this technique in the detection of gastroenteropancreatic carcinoid tumours and their metastases in comparison with conventional imaging methods. Methods: In 24 patients with confirmed carcinoids and 7 under investigation SRS was performed. The results were compared with those of conventional imaging methods (chest X-ray, upper abdominal US, chest CT, upper and lower abdominal CT) and other combinations. Results: SRS visualized primary or metastatic sites in 71.0% of cases vs 61.3% of conventional imaging. The diagnostic sensitivity of the method was higher in patients with suspected lesions (85.7% vs 57.1%). SRS was less sensitive in the detection of metastatic sites (78.9% vs 84.2%). The metastatic sites undetectable by SRS were all in the liver. Between several imaging combinations, the combinations chest X-ray/upper abdominal CT/SRS and chest CT/upper abdominal CT/SRS showed the highest sensitivity (88.75%) in terms of the number of detected lesions. The combinations chest X-ray/upper abdominal US/SRS and chest CT/upper abdominal US/SRS yielded a similar sensitivity (82%). Conclusions: SRS imaging is a very sensitive method for the detection of gastroenteropancreatic carcinoids but is less sensitive than US and CT in the detection of liver metastases. Between several imaging combinations, the combination chest x-ray/upper abdominal CT/SRS showed the highest sensitivity. Key words: Somatostatin receptors scintigraphy, gastroenteropancreatic carcinoids, cost effectiveness (EN)

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Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Society of Gastroenterology (EN)

2007-03-19


Hellenic Society of Gastroenterology (EN)

1792-7463
1108-7471
Annals of Gastroenterology; Volume 16, No 4 (2003) (EN)



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