Diagnostic approach to Helicobacter pylori-related gastric oncogenesis

 
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Annals of Gastroenterology
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Σημασιολογικός εμπλουτισμός από το EKT
Τμήμα περιοδικού (EL)
Επιστημονικό άρθρο (EL)
Βιβλιοκρισία / Βιβλιοπαρουσίαση (EL)
2022 (EL)
Diagnostic approach to Helicobacter pylori-related gastric oncogenesis (EN)
Kuntzen, Thomas
Papaefthymiou, Apostolis
Chatzimichael, Eleftherios
Doulberis, Michael
Kountouras, Jannis
Spreitzer, Stefan
Rupp, Sebastian
Polyzos, Stergios A.
Helicobacter pylori (H. pylori) is a causative agent of peptic ulcer disease and plays an important role in the development of various other upper and lower gastrointestinal tract and systemic diseases; in addition to carcinogenesis and the development of mucosa-associated lymphoid tissue lymphoma, extragastric manifestations of H. pylori are increasingly being unraveled. Therefore, prompt and accurate diagnosis is essential. Within this narrative review we present an overview of the current trend in the diagnosis of H. pylori infection and its potential oncogenic sequelae, including gastric mucosa atrophy, intestinal metaplasia, dysplasia and gastric cancer. Signs of H. pylori-related gastric cancer risk can be assessed by endoscopy using the Kyoto classification score. New technology, such as optical or digital chromoendoscopy, improves diagnostic accuracy and provides information regarding H. pylori-related gastric preneoplastic and malignant lesions. In addition, a rapid urease test or histological examination should be performed, as these offer a high diagnostic sensitivity; both are also useful for the diagnosis of sequelae including gastric and colon neoplasms. Culture is necessary for resistance testing and detecting H. pylori-related gastric dysbiosis involved in gastric oncogenesis. Likewise, molecular methods can be utilized for resistance testing and detecting H. pylori-related gastric cancer development and progression. Noninvasive tests, such as the urea breath and stool antigen tests, can also be implemented; these are also suitable for monitoring eradication success and possibly for detecting H. pylori-related gastric malignancy. Serological tests may help to exclude infection in specific populations and detect gastric and colon cancers. Finally, there are emerging potential diagnostic biomarkers for H. pylori-related gastric cancer. Keywords Helicobacter pylori, diagnosis, rapid urease test, urea breath test, histology Ann Gastroenterol 2022; 35 (4): 333-344 (EN)
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Ελληνική Γαστροεντερολογική Εταιρία
Annals of Gastroenterology
Review Article
Αγγλική γλώσσα
2022-06-27
http://www.annalsgastro.gr/index.php/annalsgastro/article/view/6228
Hellenic Society of Gastroenterology (EN)
1792-7463
1108-7471
Annals of Gastroenterology; Volume 35, No 4 (2022); 333 (EN)
Copyright (c) 2022 Annals of Gastroenterology (EN)



*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.