A case of Mixed Hepatocellular Carcinoma and Cholangiocarcinoma in a 27-year-old female patient with ulcerative colitis

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Annals of Gastroenterology
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A case of Mixed Hepatocellular Carcinoma and Cholangiocarcinoma in a 27-year-old female patient with ulcerative colitis (EN)

Koliouskas D.,
Ziakas A.,
Patsiaoura K.,
Eleftheriadis N.,
Lazaraki G.,
Sidiropoulos J.,

SUMMARY We report the case of a 27-year-old female patient, with 8- year history of ulcerative colitis (UC), admitted to our department because of exacerbation of the disease. Hematology and blood chemistry results confirmed the diagnosis of UC exacerbation. Abdominal CT detected a left liver lobe mass. Needle biopsy histological examination demonstrated adenocarcinoma. The patient was treated with left hepatic lobectomy. Histopathology of the resected lobe revealed the presence of Mixed Hepatocellular Carcinoma and Cholangiocarcinoma (MHCC) and changes characteristic of sclerosing cholangitis of small bile ducts at a distance from the carcinomatous areas. Our patient had no previous history of liver disease. Liver function tests were normal, except for mild increase in ã­‡T and alkaline phosphatase. Serum values of CEA and CA19-9 were quite elevated, while AFP was normal. The association of cholangiocarcinoma with UC is well established, while MHCC is reported in a few case reports. Primary sclerosing cholangitis (PSC) of intrahepatic (pericholangitis) or extrahepatic (classic PSC) bile ducts usually precedes the development of cholangiocarcinoma, occasionally asymptomatic. MHCC is a rare hepatobiliary complication of UC, probably in preexisting, asymptomatic PSC of small bile ducts. The issue of liver manifestations in patients with UC is discussed here. Key words: ulcerative colitis, mixed hepatocellular carcinoma and cholangiocarcinoma, pericholangitis (EN)


Αγγλική γλώσσα


Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 14, No 4 (2001) (EN)

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