The most important natural hazard in Greece is earthquake. The earthquake phenomenon can be explained using the theory of Plate Tectonics. Greece lies in the middle of the collision between two major tectonic plates, the Eurasian and the African, resulting in a very fragmented geotectonic regime. From the point of energy released, half of the European seismic energy is released within the Greek territory. Thus, the ways and means of reducing the seismic risk, that is the consequences from an earthquake, is for Greece of vital importance. The seismic risk is the convolution of the seismic hazard and the vulnerability of the specific area. From those factors, the vulnerability, which expresses the weakness or the sensitivity of the system and the value at risk during an earthquake, is the only parameter that can and should be minimized. The accomplishment of such an important task requires a combination of top-down and bottom-up approaches. In terms of the top-down approach, the Earthquake Planning and Protection Organisation’s, (E.P.P.O.), main target is to plan the national policy for earthquake protection, as well as to coordinate the public and private resources for the implementation of this policy, through issuing regulations, guidelines for emergency situation or for strengthening existing buildings including monuments of cultural heritage value e.t.c. EPPO also has a strong educational/training focus, targeting inter alia schools and hospitals. Of importance are also bottom up approaches, often at the personal level, which include useful measures concerning the proper behaviour before, during and after a destructive earthquake. These approaches are also part of the EPPO mandate and focus.