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Global DNA hypomethylation-induced Delta Np73 transcriptional activation in non-small cell lung cancer

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Global DNA hypomethylation-induced Delta Np73 transcriptional activation in non-small cell lung cancer
Logotheti, Stella
Gosney, John R.
Ζουμπουρλής, Βασίλης
Field, John K.
Xinarianos, George
Daskalos, Alexandros
Kastania, Anastasia N.
Liloglou, Triantafillos
Markopoulou, Soultana
Άρθρο σε επιστημονικό περιοδικό
2011-01-01
CLARE
p73 possesses an extrinsic P1 promoter and an intrinsic P2 promoter controlling the expression of the pro-apoptotic TAp73 isoforms and the anti-apoptotic Delta Np73 isoforms respectively In this study we investigated the DNA methylation status of both promoters as a means of epigenetic transcriptional control of their corresponding isoforms in 102 primary non-small cell lung carcinomas (NSCLCs) We demonstrated that while P1 hypermethylation-associated reduction of TAp73 mRNA levels is relatively infrequent the P2 hypomethylation-associated over-expression of Delta Np73 mRNA is a frequent event particularly among squamous cell carcinomas P2 hypomethylation strongly correlated with LINE-1 element hypomethylation indicating that Delta Np73 over-expression may be a passive consequence of global DNA hypomethylation
Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες) (EL)
Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) (EN)
TAp73
Lung cancer
Delta Np73
DNA methylation
p73
English
Elsevier Ireland Limited
Cancer Letters
https://rightsstatements.org/page/InC/1.0/?language=en
© 2010 Elsevier Ireland Ltd All rights reserved
© 2010 Elsevier Ireland Ltd All rights reserved (EN)
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)



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