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Sesquiterpene Lactones from Anthemis melanolepis and Their Antibacterial and Cytotoxic Activities. Prediction of Their Pharmacokinetic Profile

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Sesquiterpene Lactones from Anthemis melanolepis and Their Antibacterial and Cytotoxic Activities. Prediction of Their Pharmacokinetic Profile
Dimas, Kostas
Saroglou, Vasiliki
Koukoulitsa, Catherine
Skaltsa, Helen
Karioti, Anastasia
Rancic, Ana
Ζερβού, Μαρία
Άρθρο σε επιστημονικό περιοδικό
2010-02
Nine sesquiterpene lactones, anthemin A (1), 1 alpha-hydroxydeacetylirinol-4 alpha,5 beta-epoxide (2), anthemin C (3), tatridin A (4), 1-epi-tatridin B (5), anthemin B (6), 6-deacetyl-beta-cyclopyrethrosin (7), elegalactone A (8), and 1 beta,4 alpha,6 alpha-trihydroxyeudesm-11-en-8 alpha-12-olide (9), were isolated front the aerial parts of A. melanolepis in addition to eight known flavonoids and three phenolic acids. Compounds 1, 3, and 6 are new natural products. The structures of the compounds were deduced by spectroscopic methods. The in vitro antimicrobial potential of the isolated sesquiterpene lactones four Gram-positive and five Gram-negative bacteria and One fungus was evaluated using the against microdilution method, and their in vitro cytotoxic activity was determined against a panel of human tumor cell lines. Furthermore. The pharmacokinetic profile Of the sesquiterpene lactones was investigated using computational methods.
Washington
Καλλιέργεια (EL)
Χημεία (Γενικά) (EL)
Φαρμακευτική (EL)
Plant culture (EN)
Pharmacy and materia medica (EN)
Chemistry (General) (EN)
Chemistry, Medicinal
English
American Chemical Society
Journal of Natural Products
© AMER CHEMICAL SOC
© AMER CHEMICAL SOC (EN)
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)



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