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Impact of β-glucan on the Fecal Water Genotoxicity of Polypectomized Patients

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Impact of β-glucan on the Fecal Water Genotoxicity of Polypectomized Patients
Turunen K.T.
Kyriacou A.
Triantafillidis J.K.
Γεωργιάδης, Παναγιώτης
Karamanolis D.
Πλέτσα, Βασιλική
Άρθρο σε επιστημονικό περιοδικό
2016
The aim of the study was to determine the effect of β-glucan on the cytotoxicity and genotoxicity of polypectomized patient's fecal water (FW). Polypectomized volunteers (n = 69) were randomly assigned to consume bread with or without β-glucan, for 3 months. FW was collected at the beginning (t = 0), the 30th and 90th day and 2 wk after the intervention. Cytotoxicity and genotoxicity were estimated on Caco-2 cells, using trypan blue exclusion test and comet assay, respectively. Gastrointestinal symptoms were recorded and subjects kept a 3-day food diary at baseline and after completion. Trypan blue exclusion test revealed cell survival of approximately 87% after incubation with FW. The FW samples showed 49% genotoxicity at the baseline. Genotoxicity in the intervention group decreased during the trial reaching statistical significance on the 90th day compared to control. An increase was noticed 2 wk after the trial, but it still remained significantly lower compared to control. Group-specific analysis for β-glucan also revealed significant decrease in the genotoxicity on the 90th day compared to baseline. β-glucan ingestion in polypectomized patients significantly decreased the genotoxicity of their FW. Our findings suggest that β-glucan consumption could possibly provide protection against colon cancer development.
Τοξικολογία (EL)
Toxicology. Poisons (EN)
English
Routledge
Nutrition and Cancer
© 2016 Taylor & Francis Group, LLC.
© 2016 Taylor & Francis Group, LLC. (EN)
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)



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