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Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

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Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
Mohlke K.L.
Chang L.-C.
Hazen S.L.
Matsubara T.
McCarthy M.I.
Spiering W.
Rahman M.
Wang Y.
Aung T.
Kähönen M.
TPham S.
Wolffenbuttel B.H.W.
Li H.
Franke A.
Sarju R.
Tragante V.
Ichihara S.
Kato N.
Hixso E.J.A.
Vaarasmaki M.
Akiyama K.
Yamaguchi S.
Chen P.
NKelly T.
Liewald D.C.M.
Samani N.J.
Nakatochi M.
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CHopewell J.
Asif R.
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Nikus K.
Hofman A.
Waldenberger M.
Bjonnes A.
White J.
Tong L.
NNguyen Q.
Liu J.
Luan J.
Tang W.H.W.
Harambir D.
Kasturiratne A.
THeijman B.
Danesh J.
Van Meurs J.B.J.
Meitinger T.
Kim B.-J.
Zhou X.
Huang W.
Lyytikäinen L.-P.
Milani L.
Uitterlinden A.G.
Abbott J.
Szymczak S.
Yuan J.-M.
Asselbergs F.W.
Pinidiyapathirage M.J.
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Tabara Y.
Ahmed A.
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Braun T.R.
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Miki T.
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Clarke R.
Bonder M.J.
Sala C.F.
Chen C.-H.
Mihailov E.
Lieb W.
Sorice R.
Chen Y.-T.
Edwards T.L.
Hartikainen A.-L.
Davies G.
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Van Veldhuisen D.J.
Kim Y.J.
Shu X.-O.
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Wickremasinghe A.R.
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Starr J.M.
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Franco O.H.
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Κυρτόπουλος, Σωτήριος Α.
Saxena R.
Gao Y.-T.
Sapari N.S.
Stolk L.
Müller-Nurasyid M.
Dam R.M.
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Jarvelin M.-R.
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Holbrook J.D.
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Sugiyama T.
Adair L.S.
Xiang Y.-B.
Elliott P.
Collins R.
Wilson R.
Chambers J.C.
Wang X.
WKoivula R.
Ahluwalia T.S.
Kajio H.
Zhang W.
Matsushita Y.
Άρθρο σε επιστημονικό περιοδικό
2015
We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10 -11 to 5.0 × 10 -21). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10 -6). Our results provide new evidence for the role of DNA methylation in blood pressure regulation.
Γενετική (EL)
Genetics (EN)
English
Nature Publishing Group
Nature Genetics
© 2015 Nature America, Inc.
© 2015 Nature America, Inc. (EN)
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)



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