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Prevalence and loads of torquetenovirus in the european MARK-AGE study population

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Prevalence and loads of torquetenovirus in the european MARK-AGE study population
Spezia, Pietro Giorgio
Hurme, Mikko
Grubeck-Loebenstein, Beatrix
Provinciali, Mauro
Moreno-Villanueva, María
Slagboom, Eline
Bürkle, Alexander
Janiszewska, Dorota
Giacconi, Robertina
Pistello, Mauro
Debacq-Chainiaux, Florence
Γκόνος, Ευστάθιος
Basso, Andrea
Dollé, Martijn E T
Macera, Lisa
Toussaint, Olivier
Piacenza, Francesco
Hervonen, Antti
Dudkowska, Magdalena
Franceschi, Claudio
Breusing, Nicolle
Schön, Christiane
Bernhardt, Jürgen
Grune, Tilman
Jansen, Eugène
Stuetz, Wolfgang
Malavolta, Marco
Mocchegiani, Eugenio
Capri, Miriam
Sikora, Ewa
Maggi, Fabrizio
Άρθρο σε επιστημονικό περιοδικό
2020-09-25
Torquetenovirus (TTV) viremia has been associated with increased mortality risk in the elderly population. This work aims to investigate TTV viremia as a potential biomarker of immunosenescence. We compared levels of circulating TTV in 1813 participants of the MARK-AGE project, including human models of delayed (offspring of centenarians [GO]) and premature (Down syndrome [DS]) immunosenescence. The TTV load was positively associated with age, cytomegalovirus (CMV) antibody levels, and the Cu/Zn ratio and negatively associated with platelets, total cholesterol, and total IgM. TTV viremia was highest in DS and lowest in GO, with intermediate levels in the SGO (spouses of GO) and RASIG (Randomly Recruited Age-Stratified Individuals From The General Population) populations. In the RASIG population, TTV DNA loads showed a slight negative association with CD3+T-cells and CD4+T-cells. Finally, males with ≥4log TTV copies/mL had a higher risk of having a CD4/CD8 ratio<1 than those with lower viremia (odds ratio [OR] = 2.85, 95% confidence interval [CI]: 1.06-7.62), as well as reduced CD3+ and CD4+T-cells compared to males with lower replication rates (<4log), even after adjusting for CMV infection. In summary, differences in immune system preservation are reflected in the models of delayed and premature immunosenescence, displaying the best and worst control over TTV replication, respectively. In the general population, TTV loads were negatively associated with CD4+ cell counts, with an increased predisposition for an inverted CD4/CD8 ratio for individuals with TTV loads ≥4log copies/mL, thus promoting an immune risk phenotype.
Ανοσολογία (EL)
Κυτταρολογία (EL)
Βιολογία (Γενικά) (EL)
Μικροβιολογία (EL)
Βιοχημεία (EL)
Ιατρική (EL)
Ιολογία (EL)
Medicine (EN)
Biology (General) (EN)
Immunology (EN)
Microbiology (EN)
Cytology (EN)
Biochemistry (EN)
Virology (EN)
Cytomegalovirus (EN)
Prevalence (EN)
Age Factors (EN)
Cross-Sectional Studies (EN)
Viremia (EN)
Humans (EN)
Middle Aged (EN)
Torque teno virus (EN)
Male (EN)
Down syndrome (EN)
Viral Load (EN)
Down Syndrome (EN)
DNA Virus Infections (EN)
CD4/CD8 ratio (EN)
TTV (EN)
Aging (EN)
Lymphocyte Count (EN)
Immunosenescence (EN)
Adult (EN)
Female (EN)
Aged (EN)
English
Europe
The journals of gerontology. Series A, Biological sciences and medical sciences
https://creativecommons.org/licenses/by-nc-sa/4.0/deed.el
Copyright © 2020 The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)



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