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Ageladine A, a Bromopyrrole Alkaloid from the Marine Sponge Agelas nakamurai

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Ageladine A, a Bromopyrrole Alkaloid from the Marine Sponge Agelas nakamurai
Μαγουλάς, Γιώργος
Άρθρο σε επιστημονικό περιοδικό
2023
During the last three decades, secondary metabolites of marine origin have emerged as a significant source of bioactive compounds. Among the marine organisms explored, sponges offer a vast number of metabolites with unique structural diversity and a plethora of biological activities. Ageladine A, a fluorescent bromopyrrole alkaloid isolated from the marine sponge Agelas nakamurai, exhibited matrix metalloproteinase (MMP) inhibitory properties, as well as antiangiogenic activity. Due to this interesting biological profile, Ageladine A became, soon after its discovery, a target for total synthesis. In addition, a significant number of derivatives have been synthesized, and their biological activity was evaluated. The present review highlights all the successful efforts made towards the synthesis of Ageladine A. Furthermore, all the medicinal chemistry approaches to identify and assess new more potent inhibitors and to elucidate the structural features responsible for the activity are described.
Φαρμακευτική χημεία (EL)
Βιοχημεία (EL)
Χημική Βιολογία (EL)
Βιοτεχνολογία (EL)
Biotechnology (EN)
Chemical Biology (EN)
Biochemistry (EN)
Pharmaceutical chemistry (EN)
Marine natural products (EN)
MMP inhibitors (EN)
Fluorescence (EN)
Ageladine A (EN)
Agelas nakamurai (EN)
Total synthesis (EN)
Antiangiogenic activity (EN)
English
Compounds
© 2023 by the author. Licensee MDPI, Basel, Switzerland.
https://creativecommons.org/licenses/by/4.0/deed.el
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)



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