Pharmacological and phytochemical studies of Cephäelis axillaris

 
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1994 (EN)
Pharmacological and phytochemical studies of Cephäelis axillaris (EN)

Καρίκας, Γεώργιος-Αλβέρτος (EL)
Martín, M.L. (EN)
Gordaliza, M. (EN)
Gupta, M.P. (EN)
Ortiz de Urbina, A.V. (EN)

Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίων (EL)
Miguel del Corral, J.M. (EN)
San Feliciano, A. (EN)
San Roman, L. (EN)
Sanchez, C. (EN)

The most significant effect, observed in the preliminary pharmacological evaluation of the whole ethanol extract and the alkaloidal fraction of Cephäelis axillaris, was the hyperemia of ears and external mucosas which was most probably due to an alpha-adrenergic blocking activity. In addition, both samples also induced a marked hypotension in normotensive as well as hypertensive (SHR) rats and inhibited the increases of blood pressure induced by i.v. administration of noradrenaline in pithed rats. The structures of the major alkaloidal components of the extract were elucidated on the basis of chemical characterization assays and IR, UV, 1H and 13C one and two-dimensional NMR analyses. (EN)

journalArticle

alkaloidal fraction (EN)
άλφα-αδρενεργικό (EN)
Alpha adrenoceptors (EN)
υπεραιμία των αυτιών (EN)
αλκαλοειδές κλάσμα (EN)
hyperemia of ears (EN)
υπόταση (EN)
Hypotension (EN)

ΤΕΙ Αθήνας (EL)
Technological Educational Institute of Athens (EN)

Planta medica (EN)

English

1994-12


N/A (EN)



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