Burden of organochlorine substances as a risk factor of breast cancer

Burden of organochlorine substances as a risk factor of breast cancer (EN)

Λάζαρης, Ανδρέας (EL)

Γουρουντή, Κλεάνθη (EL)

journalArticle

2014-07-20

2014-07-20T09:53:35Z

2009-03

2009-01

Health Science Journal (EN)

Review article (EN)

Background: Organochlorines are a various group of synthetic chemicals that include polychlorinated biphenyls (PCBs), dibenzo- p- dioxins/ polychlorinated dibenzofurans (PCDDs/ PCDFs or dioxins) and organochlorine pesticides, such as dichlorodiphenyl-trichloroethane (DDT), lindane, aldrin and dieldrin. As many organochlorines and their metabolites have carcinogenic and the weak hormonal (estrogenic and anti-estrogenic) effects, a possible association between breast cancer risk and exposure to organochlorines has been hypothesized. It has been estimated that well established risk factors explain only about 41% of breast cancer cases, with the remainder cases due to unidentified causes. Since known risk factors for breast cancer account only for about half of all cases, there has been continued interest in the role of organochlorines and other environmental pollutants in unexplained breast cancer. Methods: The literature concerning the association between organochlorines and risk of breast cancer was reviewed. Relevant studies were identified by searching the following databases: the Cochrane Library, Medline, Embase and PubMed. Studies that met the quality criteria included in the review. Results: Association between organochlorines, such as DDT and PCBs, and breast cancer risk has been reported in a number of epidemiological studies since 1976. The association of PCBs and DDE with breast cancer has been investigated in a series of retrospective case-control studies and in prospective nested case-control studies. In general, the individual epidemiological studies that have been conducted to date and are presented in this review, do not support a positive association between body burdens of single organochlorines and the development of breast cancer. However, the quality of available scientific information is low because the majority of epidemiological studies that have been conducted till now have many limitations and weaknesses. Conclusion: This review shows that high concentration of single organochlorine compounds are not important predictors for breast cancer. However, a hypothetical association between organochlorine substances and risk of breast cancer cannot be investigated on the basis of single substances levels. The possible synergetic, antagonistic or additive interactions between the substances should be considered. Further research on interactions between organochlorines and other xenoestrogens and natural estrogens is recommended. (EN)

**N/A**-Ιατρική

http://id.loc.gov/authorities/subjects/sh85095542

http://id.loc.gov/authorities/subjects/sh2010008350

Breast--Cancer--Adjuvant treatment

Dioxins

http://id.loc.gov/authorities/subjects/sh2008020233

Oncology

**N/A**-Ογκολογία

**N/A**-Γυναικολογία

Endocrine disrupting chemicals

Ενδοκρινείς διαταραχές

Hormone receptors

Ογκολογία

Organochlorine compounds

Διοξίνη

Ορμόνες

Καρκίνος του μαστού

Gynecology

Breast--Cancer--Risk factors

http://id.loc.gov/authorities/subjects/sh85094724

Ιατρική

Γυναικολογία

Medicine

http://id.loc.gov/authorities/subjects/sh2009117568

Κίνδυνος

http://id.loc.gov/authorities/subjects/sh00006614

http://id.loc.gov/authorities/subjects/sh85058092

http://id.loc.gov/authorities/subjects/sh85038140

Οργανοχλωριούχος ένωση

http://id.loc.gov/authorities/subjects/sh85061978

Μαρβάκη, Χριστίνα (EL)

Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας.Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Νοσηλευτικής (EL)

www.hsj.gr (EN)

Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες

http://creativecommons.org/licenses/by-nc-nd/3.0/us/

free

Technological Educational Institute of Athens

Ypatia - Institutional Repository

Τόμος 3, τεύχος 1 (Ιαν. - Μαρ. 2009)