δείτε την πρωτότυπη σελίδα τεκμηρίου στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*
Metformin hydrochloride sustained release tablet using different matrixing tablet
(EN)
Sustained release dosage forms continue to draw attention in the search for
improved patient compliance & decreased incidences of adverse drug reactions. The
objective of this work was to prepare & evaluate sustained release matrix tablets of
Metformin HCl using different polymers. Metformin HCl is a water soluble drug
indicated to improve glycemic control in patients with type II diabetes. Metformin
HCl Matrix tablets were prepared using different polymers like Carbopol 971,
Xanthan gum, hydroxypropyl methyl cellulose K100M, Carbopol 71G by wet
granulation technique. Prepared tablets were evaluated for weight variation test,
hardness, friability, uniformity of content, assay & in vitro drug release. Influence of
different parameters like pH, agitation intensity on drug release was studied for
optimized batch. Metformin HCl sustained release matrix tablets prepared using
HPMC K100M was found to have higher drug content 99±0.5 % w/w & better drug
release profile 95±3 % after 12 hrs & hence it was optimized. In vitro release profile
of optimized formulations was found to be similar to that of commercial marketed
products. The average f2 values were found to be 56.47 for matrix tablets. Likewise
other water soluble drugs can also be formulated for sustained release matrix system.
(EN)
*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.
Βοηθείστε μας να κάνουμε καλύτερο το OpenArchives.gr.
