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In vitro release of new quinolones from biodegradable systems: A comparative study

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National Technical University of Athens   

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In vitro release of new quinolones from biodegradable systems: A comparative study (EN)
Tzivelekis, P (EN)
Dounis, E (EN)
Korakis, T (EN)
Kanellakopoulou, K (EN)
Andreopoulos, AG (EN)
Anastasiadis, A (EN)
journalArticle (EN)
2014-03-01T01:11:59Z
1996 (EN)
A new biodegradable delivery system based on low molecular weight poly(lactic acid) has been formualted, with potential application in the sustained antibiotic release against bone infection. The in vitro release of two new quinolones (ofloxacin and ciproftoxacin) from the biodegradable matrix showed that the delivery of ofloxacin from the matrix lasted fifty-six days, whereas that of ciprofloxacin lasted fifty-one days. In both cases, release is controlled by the drug diffusion and the matrix degradation, the latter being the most critical factor. The obtained concentration levels are well above the Minimum Inhibitory Concentration (MIC) against the major causative bacteria of osteomyelitis. This fact in combination with the good reproducibility of measurements indicated that the system studied could be of value for the preparation of implantable controlled release systems for treatment of diseases in the bone system. (EN)
Engineering, Biomedical (EN)
Materials Science, Biomaterials (EN)
lactic acid (EN)
bioremediation (EN)
Molecular Weight (EN)
culture medium (EN)
in vitro study (EN)
antiinfective agent (EN)
Quinolones (EN)
Time Factors (EN)
Culture Media (EN)
Polymers (EN)
Organic compounds (EN)
Biodegradation, Environmental (EN)
Polylactic acid (EN)
New quinolones (EN)
article (EN)
Diseases (EN)
Osteomyelitis (EN)
Minimum inhibitory concentration (EN)
drug delivery system (EN)
polymer (EN)
Drug delivery systems (EN)
comparative study (EN)
diffusion (EN)
Molecular weight (EN)
Anti-Infective Agents (EN)
Drug Carriers (EN)
Drug Delivery Systems (EN)
Controlled drug delivery (EN)
ofloxacin (EN)
polylactic acid (EN)
Bacteria (EN)
Diffusion (EN)
Biodegradation (EN)
chemistry (EN)
delayed release formulation (EN)
Lactic Acid (EN)
Organic polymers (EN)
molecular weight (EN)
Ofloxacin (EN)
Biodegradable polymers (EN)
Ciprofioxacin (EN)
Antibiotics (EN)
Bone (EN)
time (EN)
Ciprofloxacin (EN)
Delayed-Action Preparations (EN)
drug carrier (EN)
ciprofloxacin (EN)
statistics (EN)
Journal of Biomaterials Applications (EN)
English
TECHNOMIC PUBL CO INC (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
Κεντρική Βιβλιοθήκη Ε.Μ.Π.
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