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Impaired P600 in neuroleptic naive patients with first-episode schizophrenia

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Impaired P600 in neuroleptic naive patients with first-episode schizophrenia (EN)
Vasios, C (EN)
Asvestas, P (EN)
Kontopantelis, E (EN)
Stamouli, S (EN)
Matsopoulos, GK (EN)
Papageorgiou, C (EN)
Kontaxakis, VP (EN)
Rabavilas, A (EN)
Christodoulou, GN (EN)
Havaki-Kontaxaki, BJ (EN)
Uzunoglu, N (EN)
journalArticle (EN)
2014-03-01T01:16:38Z
2001 (EN)
Deficits of working memory (WM) are recognized as an important pathological feature in schizophrenia. Since the P600 component of event related potentials has been hypothesized that represents aspects of second-pass parsing processes of information processing, and is related to WM, the present study focuses on P600 elicited during a WM test in drug-naive first-episode schizophrenics (FES) compared to healthy controls. We examined 16 drug-naive first-episode schizophrenic patients and 23 healthy controls matched for age and sex. Compared with controls schizophrenic patients showed reduced P600 amplitude on left temporoparietal region and increased P600 amplitude on left occipital region. With regard to the latency, the patients exhibited significantly prolongation on right temporoparietal region. The obtained pattern of differences classified correctly 89.20% of patients. Memory performance of patients was also significantly impaired relative to controls. Our results suggest that second-pass parsing process of information processing, as indexed by P600, elicited during a WM test, is impaired in FES. Moreover, these findings lend support to the view that the auditory WM in schizophrenia involves or affects a circuitry including temporoparietal and occipital brain areas. NeuroReport 12:2801-2806 (C) 2001 Lippincott Williams & Wilkins. (EN)
Neurosciences (EN)
information processing (EN)
Predictive Value of Tests (EN)
P600 (EN)
memory (EN)
Humans (EN)
Evoked Potentials (EN)
Schizophrenia (EN)
Event-related potentials (EN)
Cerebral Cortex (EN)
Male (EN)
Reaction Time (EN)
Electroencephalography (EN)
schizophrenia (EN)
Antipsychotic Agents (EN)
clinical article (EN)
working memory (EN)
Statistical Distributions (EN)
Adult (EN)
Female (EN)
priority journal (EN)
female (EN)
human (EN)
Acoustic Stimulation (EN)
First-episode schizophrenia (EN)
Hospitalization (EN)
occipital cortex (EN)
neuroleptic agent (EN)
article (EN)
Neuropsychological Tests (EN)
amplitude modulation (EN)
event related potential (EN)
Memory Disorders (EN)
controlled study (EN)
Age of Onset (EN)
Working memory (EN)
adult (EN)
Memory, Short-Term (EN)
Chronic Disease (EN)
male (EN)
NeuroReport (EN)
English
LIPPINCOTT WILLIAMS & WILKINS (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
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