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Detection of CD55- and/or CD59-deficient red cell populations in patients with plasma cell dyscrasias

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Detection of CD55- and/or CD59-deficient red cell populations in patients with plasma cell dyscrasias (EN)
Viniou, N (EN)
Korovesis, K (EN)
Mavrogianni, D (EN)
Samarkos, M (EN)
Apostolidou, E (EN)
Meletis, J (EN)
Variami, E (EN)
Komninaka, V (EN)
Konstantopoulos, K (EN)
Meletis, C (EN)
Anargyrou, K (EN)
Terpos, E (EN)
Benopoulou, O (EN)
journalArticle (EN)
2014-03-01T01:17:41Z
2002 (EN)
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disorder characterized by a decrease or absence of glycosylphosphatidylinositol (GPI)-anchored molecules such as CD55 and CD59 from the surface of affected cells. resulting in intravascular hemolysis. cytopenia, and venous thrombosis. A PNH-like phenotype has been detected in various hematological disorders, mainly in aplastic anemia and myelodysplastic syndromes, but also in lymphoproliferative syndromes (LPSs). To the best of our knowledge. CD55- or CD59-deficient red cells have not been detected in Plasma cell dyscrasias (PCDs). The aim of this study was the detection of CD55- and/or CD59-deficient red cell populations in patients with PCD. Seventy-seven patients were evaluated; 62 with multiple myeloma (MM), 7 with Waldenstrom macroglobulinemia (WM), 6 with monoclonal gammopathy of undetermined significance (MGUS), and 2 with heavy chain disease (HCD). The sephacryl gel microtyping system was applied: Ham and sucrose lysis tests were also performed on all samples with CD55- or CD59-negative populations. Red cells deficient in both molecules were detected in 10 (12.9%) of 77 patients with PCD: 2 (28.6%) of 7 with WM, 1 (16.6%) of 6 with MGUS, 6 (9.6%) of 62 with MM, and 1 of 2 patients with HCD. Isolated CD55 deficiency was found in 28.5% of all PCD patients. whereas isolated CD59 deficiency was not observed in any patients. These findings illustrate the existence of the PNH phenotype in the red cells of patients with PCD: further investigation is needed into the mechanisms and significance of this phenotype. Int J Hematol. 2002;75:40-44. (C) 2002 The Japanese Society of Hematology. (EN)
Hematology (EN)
monoclonal immunoglobulinemia (EN)
multiple myeloma (EN)
paroxysmal nocturnal hemoglobinuria (EN)
Waldenstroem macroglobulinemia (EN)
decay accelerating factor (EN)
Multiple myeloma (EN)
Paroxysmal nocturnal hemoglobinuria (EN)
CD59 antigen (EN)
plasma cell dyscrasia (EN)
Waldenström macroglobulinemia (EN)
article (EN)
erythrocyte (EN)
CD59 (EN)
heavy chain disease (EN)
human (EN)
CD55 (EN)
International Journal of Hematology (EN)
English
CARDEN JENNINGS PUBL CO LTD (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
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