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Release of propranolol and diclofenac from low Mw DL-poly(lactic acid)

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National Technical University of Athens   

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Release of propranolol and diclofenac from low Mw DL-poly(lactic acid) (EN)
Proikakis, CS (EN)
Mamouzelos, NJ (EN)
Tarantili, PA (EN)
Andreopoulos, AG (EN)
journalArticle (EN)
2014-03-01T01:18:17Z
2002 (EN)
The controlled release of two drugs, i.e. the sodium salt of diclofenac and propranolol was studied, by using low molecular weight D,L-Poly(lactic acid) as a matrix. Tablets of the above polymer containing those drugs were immersed into buffers with various pH values and delivery was recorded as a function of time, via UV-spectroscopy. The results showed that the polymer is appropriate for such biomedical applications, as generally, it ensures complete drug delivery within 45-60 days, which is acceptable for most cases. On the other hand, the release rate depends on many parameters including the interactions among drug, matrix and the surrounding liquid, which adds complexity to the process and requires careful investigation for proper design of a controlled release system. (EN)
Engineering, Biomedical (EN)
Materials Science, Biomaterials (EN)
lactic acid (EN)
polymer (EN)
Viscosity (EN)
Molecular Weight (EN)
biomaterial (EN)
Ultraviolet spectroscopy (EN)
Spectroscopy, Fourier Transform Infrared (EN)
Molecular weight (EN)
Diclofenac (EN)
Biomaterials (EN)
Drug Carriers (EN)
Controlled drug delivery (EN)
polylactic acid (EN)
propranolol (EN)
pH (EN)
Propranolol (EN)
Polymers (EN)
Controlled release (EN)
Biomedical engineering (EN)
infrared spectroscopy (EN)
Biodegradation (EN)
chemistry (EN)
delayed release formulation (EN)
Lactic Acid (EN)
Polylactic acid (EN)
Polymerization (EN)
Organic polymers (EN)
molecular weight (EN)
Biodegradable systems (EN)
article (EN)
DL-poly(lactic acid) (EN)
viscosity (EN)
differential scanning calorimetry (EN)
Biocompatible Materials (EN)
Calorimetry, Differential Scanning (EN)
Propanolol (EN)
diclofenac (EN)
Delayed-Action Preparations (EN)
drug carrier (EN)
Hydrogen-Ion Concentration (EN)
Journal of Biomaterials Applications (EN)
English
SAGE PUBLICATIONS LTD (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
Κεντρική Βιβλιοθήκη Ε.Μ.Π.
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