Do atypical antipsychotics fail to exert cognitive sparing effects?

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Do atypical antipsychotics fail to exert cognitive sparing effects? (EN)

Oulis, P (EN)
Vasios, C (EN)
Matsopoulos, GK (EN)
Papageorgiou, C (EN)
Rabavilas, A (EN)
Christodoulou, GN (EN)
Uzunoglu, N (EN)

journalArticle (EN)

2014-03-01T01:18:53Z
2003 (EN)


The aim of the study was to investigate patterns of the P600 component of event-related potentials (ERPs) elicited during a working memory test in 16 male schizophrenic patients experiencing auditory hallucinations before and after treatment with clozapine and olanzapine, and 13 male normal subjects matched for age and educational level. Before treatment, patients showed significantly reduced P600 amplitudes on the right parietal region compared with controls, and when in remission also showed significantly reduced P600 amplitudes located on the right parietal and temporofrontal areas, compared both to themselves before treatment and to normal controls. The patient's memory performance before and after treatment remained significantly lower than that of healthy controls. These findings may indicate that auditory hallucinations in schizophrenia are associated with impaired synchronization of the processes related to target detection, as reflected by the P600. The present study also casts doubts regarding the cognitive sparing effect of atypical antipsychotics, despite the fact that they mediate symptom improvement. © 2003 Lippincott Williams & Wilkins. (EN)

Neurosciences (EN)

Brain (EN)
Atypical antipsychotics (EN)
Olanzapine (EN)
P600 (EN)
memory (EN)
Humans (EN)
Memory (EN)
Auditory hallucinations (EN)
Schizophrenia (EN)
Male (EN)
Reference Values (EN)
Cognition (EN)
schizophrenia (EN)
Schizophrenic Psychology (EN)
olanzapine (EN)
Antipsychotic Agents (EN)
Psychiatric Status Rating Scales (EN)
clinical article (EN)
working memory (EN)
Adult (EN)
priority journal (EN)
human (EN)
cognition (EN)
Double-Blind Method (EN)
Clozapine (EN)
neuroleptic agent (EN)
article (EN)
Benzodiazepines (EN)
Evoked Potentials, Auditory (EN)
event related potential (EN)
controlled study (EN)
Hallucinations (EN)
clozapine (EN)
Pirenzepine (EN)
Working memory (EN)
auditory hallucination (EN)
adult (EN)
male (EN)

NeuroReport (EN)

Αγγλική γλώσσα

LIPPINCOTT WILLIAMS & WILKINS (EN)




*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.