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A four-dimensional simulation model of tumour response to radiotherapy in vivo: Parametric validation considering radiosensitivity, genetic profile and fractionation

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National Technical University of Athens   

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A four-dimensional simulation model of tumour response to radiotherapy in vivo: Parametric validation considering radiosensitivity, genetic profile and fractionation (EN)
Stamatakos, GS (EN)
Uzunoglu, NK (EN)
Nikita, KS (EN)
Marioli, A (EN)
Dionysiou, DD (EN)
journalArticle (EN)
2014-03-01T01:19:44Z
2004 (EN)
The aim of this paper is to present the current state of a four-dimensional simulation model of solid tumour growth and response to radiotherapy developed by our group. The most prominent points of the algorithms describing the fundamental biological phenomena involved are outlined. A specific application of the model to a selected clinical case of glioblastoma multiforme is described and comparative studies are performed, using various exploratory values of the model parameters. Qualitative agreement with clinical observations has been achieved. Special emphasis is laid on the variability of radiosensitivity parameters throughout the cell cycle and on the influence of the genetic profile of the tumour on its radiosensitivity. The results of the simulation are three-dimensionally reconstructed. A valuable tool for getting insight into the biology of tumour growth and response to radiotherapy and at the same time an advanced patient specific decision support system is expected to emerge after the completion of the necessary extensive clinical evaluation. (C) 2004 Elsevier Ltd. All rights reserved. (EN)
Biology (EN)
Mathematical & Computational Biology (EN)
comparative study (EN)
theoretical study (EN)
cancer model (EN)
simulation (EN)
Humans (EN)
Radiation Tolerance (EN)
clinical examination (EN)
Glioblastoma (EN)
solid tumor (EN)
Neoplasms (EN)
Brain Neoplasms (EN)
cancer radiotherapy (EN)
genetics (EN)
analytical parameters (EN)
Cell Division (EN)
Computer Simulation (EN)
tumor growth (EN)
Modelling (EN)
Tumour (EN)
priority journal (EN)
human (EN)
Radiotherapy Planning, Computer-Assisted (EN)
algorithm (EN)
validation process (EN)
Computer simulation (EN)
cell cycle (EN)
four-dimensional modeling (EN)
radiosensitivity (EN)
Models, Statistical (EN)
Radiotherapy (EN)
article (EN)
glioblastoma (EN)
Models, Biological (EN)
tumor (EN)
decision support system (EN)
qualitative analysis (EN)
cancer (EN)
Cancer (EN)
Journal of Theoretical Biology (EN)
English
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
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