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Simulating chemotherapeutic schemes in the individualized treatment context: The paradigm of glioblastoma multiforme treated by temozolomide in vivo

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National Technical University of Athens   

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Simulating chemotherapeutic schemes in the individualized treatment context: The paradigm of glioblastoma multiforme treated by temozolomide in vivo (EN)
Stamatakos, GS (EN)
Uzunoglu, NK (EN)
Antipas, VP (EN)
journalArticle (EN)
2014-03-01T01:25:09Z
2006 (EN)
A novel patient individualized, spatiotemporal Monte Carlo simulation model of tumor response to chemotherapeutic schemes in vivo is presented. Treatment of glioblastoma multiforme by temozolomide is considered as a paradigm. The model is based on the patient's imaging, histopathologic and genetic data. A discretization mesh is superimposed upon the anatomical region of interest and within each geometrical cell of the mesh the most prominent biological "laws" (cell cycling, apoptosis, etc.) in conjunction with pharmacokinetics and pharmacodynamics information are applied. A good qualitative agreement of the model's predictions with clinical experience supports the applicability of the approach to chemotherapy optimization. (c) 2005 Elsevier Ltd. All rights reserved. (EN)
Computer Science, Interdisciplinary Applications (EN)
Engineering, Biomedical (EN)
Biology (EN)
Mathematical & Computational Biology (EN)
temozolomide (EN)
OPTIMIZING DRUG REGIMENS (EN)
glioblastoma multiforme (EN)
CANCER-CHEMOTHERAPY (EN)
in silico oncology (EN)
MATHEMATICAL METHODS (EN)
MODEL (EN)
CELL-LINES (EN)
chemotherapy (EN)
TUMORS (EN)
chemotherapy optimization (EN)
PHARMACOKINETICS (EN)
simulation model (EN)
BRAIN METASTASES (EN)
RESISTANCE (EN)
tumor growth (EN)
cancer (EN)
O-6-METHYLGUANINE-DNA METHYLTRANSFERASE (EN)
COMPUTERS IN BIOLOGY AND MEDICINE (EN)
English
PERGAMON-ELSEVIER SCIENCE LTD (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
Κεντρική Βιβλιοθήκη Ε.Μ.Π.
Ιδρυματικό Αποθετήριο
Δημοσιεύσεις μελών Δ.Ε.Π. σε περιοδικά



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