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Determination of the human brainstem respiratory control network and its cortical connections in vivo using functional and structural imaging

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National Technical University of Athens   

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Determination of the human brainstem respiratory control network and its cortical connections in vivo using functional and structural imaging (EN)
Mitsis, GD (EN)
Jbabdi, S (EN)
Dirckx, S (EN)
Rogers, R (EN)
Wise, RG (EN)
Mayhew, SD (EN)
Tracey, I (EN)
Pattinson, KTS (EN)
Harvey, AK (EN)
journalArticle (EN)
2014-03-01T01:30:09Z
2009 (EN)
This study combined functional and structural magnetic resonance imaging techniques, optimized for the human brainstem, to investigate activity in brainstem respiratory control centres in a group of 12 healthy human volunteers. We stimulated respiration with carbon dioxide (CO2), and utilized novel methodology to separate its vascular from its neuronal effects upon the blood oxygen level dependent (BOLD) signal. In the brainstem we observed activity in the dorsal rostral pons (representing the Kolliker-Fuse/parabrachial (KF/PB) nuclei and locus coeruleus), the inferior ventral pons and the dorsal and lateral medulla. These areas of activation correspond to respiratory nuclei identified in recent rodent studies. Our results also reveal functional participation of the anteroventral (AV), ventral posterolateral (VPL) ventrolateral thalamic nuclei, and the posterior putamen in the response to CO2 stimulation, suggesting that these centres may play a role in gating respiratory information to the cortex. As the functional imaging plane was limited to the brainstem and adjacent subcortical areas, we employed diffusion tractography to further investigate cortical connectivity of the thalamic activations. This revealed distinct connectivity profiles of these thalamic activations suggesting subdivision of the thalamus with regards to respiratory control. From these results we speculate that the thalamus plays an important role in integrating respiratory signals to and from the brainstem respiratory centres. (C) 2008 Elsevier Inc. All rights reserved. (EN)
Neuroimaging (EN)
Neurosciences (EN)
Radiology, Nuclear Medicine & Medical Imaging (EN)
brain cortex (EN)
Humans (EN)
respiration control (EN)
Male (EN)
diffusion weighted imaging (EN)
image analysis (EN)
Neural Pathways (EN)
respiration center (EN)
putamen (EN)
Feedback (EN)
Adult (EN)
Female (EN)
Thalamus (EN)
priority journal (EN)
female (EN)
human (EN)
thalamus (EN)
normal human (EN)
carbon dioxide (EN)
human experiment (EN)
Oxygen Consumption (EN)
article (EN)
Carbon Dioxide (EN)
pons (EN)
Magnetic Resonance Imaging (EN)
brain stem (EN)
Brain Stem (EN)
Respiratory Mechanics (EN)
adult (EN)
functional magnetic resonance imaging (EN)
male (EN)
medulla oblongata (EN)
NeuroImage (EN)
English
ACADEMIC PRESS INC ELSEVIER SCIENCE (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
Κεντρική Βιβλιοθήκη Ε.Μ.Π.
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