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Cell cycle and apoptosis regulatory gene expression in the bone marrow of patients with de novo myelodysplastic syndromes (MDS)

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Cell cycle and apoptosis regulatory gene expression in the bone marrow of patients with de novo myelodysplastic syndromes (MDS) (EN)
Pappa, V (EN)
Economopoulou, P (EN)
Papageorgiou, E (EN)
Papasteriadi, C (EN)
Girkas, K (EN)
Economopoulou, C (EN)
Kontsioti, F (EN)
Papageorgiou, S (EN)
Dervenoulas, J (EN)
Economopoulos, T (EN)
Kapsimali, V (EN)
Tsirigotis, P (EN)
Charitidou, E (EN)
journalArticle (EN)
2014-03-01T01:32:59Z
2010 (EN)
Deregulation of cell cycle and apoptosis pathways are known contributors to the pathogenesis ofmyelodysplastic syndromes (MDS). However, the underlying mechanisms are not fully clarified. The aim of our study was to examine mRNA expression levels of cell cycle and apoptosis regulatory genes, as well as the percentage of apoptotic and S phase cells and to correlate the findings with clinical characteristics and prognosis. Sixty patients with MDS, classified according to FAB (17 RA, five RARS, 19 RAEB, nine RAEBT, ten CMML) and WHO (ten RA, three RARS, seven RCMD, two RCMD-RS, 11 RAEBI, eight RAEBII, ten CMML, and nine AML) were included in the study. We found increased expression of anti-apoptotic bclxL and mcl1 genes and decreased expression of p21 gene inMDS patients. Moreover, we found increased expression of anti-apoptotic mcl1 gene in patients with higher than Intermediate-1 IPSS group. Multivariate analysis confirmed that combined expression of apoptotic caspases 8, 3, 6, 5, 2, 7, and Granzyme B was decreased in MDS patients. Regarding cell cycle regulatory genes expression, we demonstrated increased expression of cyclin D1 in patients with CMML Increased combined expression of cyclins B, C, D1, and D2 was found in patients with cytogenetic abnormalities. The two pathways seem to be interconnected as shown by the positive correlation between CDKs 1, 2, 4, p21 and the level of apoptosis and positive correlation between apoptotic caspase 3 expression and the percentage of S phase cells. In conclusion, our study showed altered expression of genes involved in apoptosis and cell cycle in MDS and increased expression of cyclin D1 in patients with CMML. © Springer-Verlag 2009. (EN)
Hematology (EN)
granzyme B (EN)
protein p21 (EN)
major clinical study (EN)
Humans (EN)
Middle Aged (EN)
cell cycle protein (EN)
cycline (EN)
Male (EN)
caspase 2 (EN)
caspase 3 (EN)
Cyclin D1 (EN)
cytogenetics (EN)
caspase 5 (EN)
Myelodysplastic syndromes (EN)
caspase 6 (EN)
caspase 7 (EN)
apoptosis regulatory protein (EN)
caspase 8 (EN)
RNA extraction (EN)
CMML (EN)
Karyotyping (EN)
S Phase (EN)
refractory anemia with ringed sideroblasts (EN)
Aged, 80 and over (EN)
flow cytometry (EN)
female (EN)
karyotyping (EN)
refractory anemia with excess blasts in transformation (EN)
cyclin C (EN)
cyclin B (EN)
ribonuclease (EN)
chronic myelomonocytic leukemia (EN)
cyclin dependent kinase 2 (EN)
cyclin dependent kinase 1 (EN)
acute granulocytic leukemia (EN)
cyclin dependent kinase 4 (EN)
article (EN)
refractory anemia (EN)
gene expression regulation (EN)
pathogenesis (EN)
protein mcl 1 (EN)
adult (EN)
gene expression (EN)
male (EN)
Cell Cycle Proteins (EN)
unclassified drug (EN)
pathology (EN)
apoptosis (EN)
genetics (EN)
messenger RNA (EN)
refractory anemia with excess blasts (EN)
Cell cycle (EN)
Female (EN)
protein bcl xl (EN)
priority journal (EN)
human (EN)
Myelodysplastic Syndromes (EN)
cell cycle S phase (EN)
cell cycle (EN)
Gene Expression Regulation (EN)
aged (EN)
middle aged (EN)
prognosis (EN)
Apoptosis Regulatory Proteins (EN)
controlled study (EN)
lipocortin 5 (EN)
cyclin D2 (EN)
cyclin D1 (EN)
Aged (EN)
myelodysplastic syndrome (EN)
Apoptosis (EN)
Annals of Hematology (EN)
Αγγλική γλώσσα
SPRINGER (EN)
Εθνικό Μετσόβιο Πολυτεχνείο
Ψηφιακό Αποθετήριο της Κεντρικής Βιβλιοθήκης του ΕΜΠ | Dspace@NTUA
Κεντρική Βιβλιοθήκη Ε.Μ.Π.
Ιδρυματικό Αποθετήριο
Δημοσιεύσεις μελών Δ.Ε.Π. σε περιοδικά



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