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Correlation of hydrolytic degradation with structure for copolyesters produced from glycolic and adipic acids

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National Technical University of Athens   

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Correlation of hydrolytic degradation with structure for copolyesters produced from glycolic and adipic acids (EN)
Soulis, S (EN)
Triantou, K (EN)
Simitzis, J (EN)
Simitzis, Ch (EN)
Triantou, D (EN)
Zoumpoulakis, L (EN)
journalArticle (EN)
2014-03-01T01:33:05Z
2010 (EN)
Copolyesters based on glycolic acid (G) combined with adipic acid (A) and ethylene glycol (E) were synthesized in different percentage of molar ratios (A: 100-50% and G: 100%) and their hydrolytic degradation was studied and correlated with their structures. According to the DSC, the production of polyesters leads to the formation of copolyesters and not to mixtures of homopolyesters. The crystallites in the copolyesters mainly consist of continuous sequences of ethylene adipate structural units. The hydrolytic degradation of the polyesters was followed by their weight loss during hydrolysis and by the FTIR spectra of the initial polyesters compared with that of the degraded polyesters at equilibrium. The region between 1142 and 800 cm-1 can be utilized to evaluate the extent of degradation of polyesters after their hydrolysis. The absorption bands at 1142, 1077 and 850 cm-1 due to the amorphous region decrease after hydrolysis, whereas those at 972, 901 and 806 cm-1 due to the crystalline region increase. The experimental data of the hydrolytic degradation were fitted with exponential rise to maximum type functions using two-parameter model, which describes very well mainly the initial part of the degradation, and four-parameter model (containing two exponential terms), which is appropriate for fitting the hydrolytic degradation on the entire time period (including the equilibrium). Furthermore, the kinetics of the hydrolytic degradation of the polyesters for the initial time period based on both models results to similar values of the rate constant, k. The synthesized copolyesters of glycolic acid combined with adipic acid and ethylene glycol are soluble in many common organic solvents opposite to PGA, leading to modified biodegradable polyesters and therefore they can be easily processed. © 2009 Springer Science+Business Media, LLC. (EN)
Engineering, Biomedical (EN)
Materials Science, Biomaterials (EN)
adipic acid (EN)
Two-parameter models (EN)
Esters (EN)
Time periods (EN)
polyester (EN)
glycolic acid (EN)
Rate Constant (EN)
Absorption band (EN)
Surface Properties (EN)
Adipic Acids (EN)
Amorphous regions (EN)
Biodegradation, Environmental (EN)
biodegradability (EN)
Initial time (EN)
Crystalline regions (EN)
Four-parameter model (EN)
Organic solvents (EN)
Materials Testing (EN)
Molar ratio (EN)
article (EN)
Glycolates (EN)
Structural unit (EN)
Homopolyesters (EN)
solubility (EN)
Biocompatible Materials (EN)
Fourier transform infrared spectroscopy (EN)
Kinetics (EN)
Temperature (EN)
Rate constants (EN)
Ethylene (EN)
degradation kinetics (EN)
Structure-Activity Relationship (EN)
Spectroscopy, Fourier Transform Infrared (EN)
Drug Carriers (EN)
Glycolic acids (EN)
Copolyesters (EN)
ethylene glycol (EN)
Biotransformation (EN)
Polyesters (EN)
Molecular Structure (EN)
Hydrolytic degradation (EN)
priority journal (EN)
Ethylene Glycol (EN)
Photodegradation (EN)
synthesis (EN)
Ethylene glycol (EN)
Experimental data (EN)
FT-IR spectrum (EN)
Weight loss (EN)
Organic Solvent (EN)
Exponential functions (EN)
Adipates (EN)
Biodegradable polyesters (EN)
Models, Statistical (EN)
Absorbable Implants (EN)
Experimental Data (EN)
Hydrolysis (EN)
controlled study (EN)
Weight Loss (EN)
chemical structure (EN)
hydrolysis (EN)
Adipic acids (EN)
Journal of Materials Science: Materials in Medicine (EN)
English
SPRINGER (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
Κεντρική Βιβλιοθήκη Ε.Μ.Π.
Ιδρυματικό Αποθετήριο
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