1. Home page
  2. Search

Sacrificial template-directed fabrication of superparamagnetic polymer microcontainers for pH-activated controlled release of Daunorubicin

This item is provided by the institution :
National Technical University of Athens   

Repository :
Digital Library of National Technical University of Athens | Dspace@NTUA   

see the original item page
in the repository's web site and access all digital files if the item*



Sacrificial template-directed fabrication of superparamagnetic polymer microcontainers for pH-activated controlled release of Daunorubicin (EN)
Efthimiadou, EK (EN)
Boukos, N (EN)
Bilalis, P (EN)
Chatzipavlidis, A (EN)
Kordas, GC (EN)
journalArticle (EN)
2014-03-01T01:36:43Z
2011 (EN)
Magnetic pH-sensitive microcontainers were produced by a four-step process. The first step involves the synthesis of citrate-modified magnetic nanoparticles via the coprecipitation method. The second step consists of the encapsulation of magnetic nanoparticles in non-cross-linked poly(methacrylic acid) (PMAA) microspheres through distillation precipitation polymerization, resulting in a core/shell structure. The third step concerns the formation of a poly(N,N′-methylenebis(acrylamide)-co-mathacrylic acid) (P(MBAAm-co-MAA)) layer on the surface of magnetic PMAA microspheres by second distillation precipitation polymerization in order to produce a trilayer hybrid microsphere. The last step deals with the removal of PMAA layer in ethanol and formation of a stable P(MBAAm-co-MAA) microcontainer with magnetic nanoparticles entrapped inside the formed cavity. This process is simple and leads to the formation of superparamagnetic pH-sensitive microcontainers. The structure and properties of the magnetic microcontainers were investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), vibrating sample magnetometry (VSM), and dynamic light scattering (DLS) to determine the functionalities of the hybrid structure. The magnetic pH-sensitive microcontainers were loaded with Daunorubicin and tested with respect to release rate at different pH values in order to evaluate their functionality as controlled release system. © 2011 American Chemical Society. (EN)
Chemistry, Physical (EN)
Vibrating sample magnetometry (EN)
particle size (EN)
Poly(methacrylic acid) (EN)
Microcontainer (EN)
Superparamagnetism (EN)
Trilayers (EN)
Microspheres (EN)
X ray diffraction analysis (EN)
Dynamic light scattering (EN)
Hybrid structure (EN)
Surface Properties (EN)
Polymers (EN)
Acrylic monomers (EN)
Distillation-precipitation polymerization (EN)
Core/shell structure (EN)
Scanning electron microscopy (EN)
pH value (EN)
Ethanol (EN)
Magnetic nanoparticles (EN)
nanoparticle (EN)
Structure and properties (EN)
article (EN)
daunorubicin (EN)
Particle Size (EN)
surface property (EN)
pH sensitive (EN)
microsphere (EN)
Fourier transform infrared spectroscopy (EN)
Hydrogen-Ion Concentration (EN)
Acrylamides (EN)
polymer (EN)
Hybrid microspheres (EN)
magnetism (EN)
Amides (EN)
Magnetics (EN)
Nanoparticles (EN)
Daunorubicin (EN)
Release rate (EN)
Coprecipitation method (EN)
pH (EN)
Molecular Structure (EN)
Precipitation (chemical) (EN)
Controlled release (EN)
Superparamagnetics (EN)
Distillation (EN)
chemistry (EN)
synthesis (EN)
Polymerization (EN)
Controlled release systems (EN)
X ray diffraction (EN)
Nanomagnetics (EN)
Transmission electron microscopy (EN)
chemical structure (EN)
Langmuir (EN)
English
AMER CHEMICAL SOC (EN)
National Technical University of Athens
Digital Library of National Technical University of Athens | Dspace@NTUA
Κεντρική Βιβλιοθήκη Ε.Μ.Π.
Ιδρυματικό Αποθετήριο
Δημοσιεύσεις μελών Δ.Ε.Π. σε περιοδικά



*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)