The role of O-2(center dot-) radicals in DNA-metal complexes

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Title

The role of O-2(center dot-) radicals in DNA-metal complexes (EN)

Creator

Theophanides, TM (EN)

Rakintzis, NT (EN)

Anastassopoulou, JD (EN)

Type

journalArticle (EN)

Partial document
Publication in journal (EN)

Article
Scientific article (EN)

Issued

2014-03-01T01:47:44Z

1998 (EN)

Year

1998 (EN)

Description

The nucleotide 5'-guanosine monophosphate (5'-GMPNa(2)) was irradiated with gamma-rays in aerated aqueous solutions in the absence as well as in the presence of cis-dichlorodiammineplatinum(II) (cis-DDP). The HPLC data of the radiolysis products suggest that O-2(.-) radicals reduce the Pt(II) complex formed to Pt(I) complex, which finally releases by disproportionation Pt metal, Pt(0). cis-DDP acts as a radiosensitizer and the irradiation in the presence of cis-DDP leads to the release of the base guanine. (C) 1998 Elsevier Science S.A. All rights reserved. (EN)

Scientific field

Chemistry, Inorganic & Nuclear (EN)

Natural Sciences ▶ Chemical sciences
Inorganic and Nuclear Chemistry (EN)

Subject

superoxide radicals (EN)

platinum complexes (EN)

DNA complexes (EN)

RADIATION (EN)

Journal

INORGANICA CHIMICA ACTA (EN)

Language

English