The cytoprotective effect of amifostine in acute radiation dermatitis: a retrospective analysis

Το τεκμήριο παρέχεται από τον φορέα :
National Technical University of Athens   

Αποθετήριο :
Digital Library of National Technical University of Athens | Dspace@NTUA   

δείτε την πρωτότυπη σελίδα τεκμηρίου
στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*



The cytoprotective effect of amifostine in acute radiation dermatitis: a retrospective analysis (EN)

Kokakis, J (EN)
Vlahos, L (EN)
Kouloulias, V (EN)
Matsopoulos, G (EN)
Myrsini, B (EN)
Kouvaris, J (EN)

journalArticle (EN)

2014-03-01T01:52:12Z
2002 (EN)


To study the impact of amifostine as a cytoprotective agent against acute radiation dermatitis, we reviewed 220 patient records. One hundred cancer patients, with tumors localised in the pelvis (bladder, rectum, prostatic carcinomas, or gynecological cancer), who received radiotherapy and cytoprotective treatment with intravenous infusion of amifostine (group A) were included in this study. Retrospectively, we randomly selected from a database in Our hospital 120 historical controls, who received only radiotherapy without cytoprotection (group B). Mean gross dermatitis score (MGDS) was the mean value of recorded acute radiation dermatitis according to common toxicity criteria. In group A versus B patients, a significantly reduced severity of dermatitis (P < 0.001, Fisher's exact test) and significant reduction of MGDS as well as mean interruption treatment time (P < 0.001, Mann-Whitney U test) was observed. The relative risk of the outcome of the two study groups was 0.23 (95% CI: 0.15 to 0.34). The significant dermato-cytoprotective effect of amifostine noticed in our retrospective analysis warrants further investigation with randomised trials. (EN)

Dermatology (EN)

cytoprotection (EN)
COLONY-STIMULATING FACTOR (EN)
TOXICITY (EN)
WR-2721 (EN)
TREATMENT TIME (EN)
NECK-CANCER (EN)
RECTAL-CANCER (EN)
dermatitis (EN)
radiotherapy (EN)
amifostine (EN)
RADIOTHERAPY (EN)
SKIN (EN)
NORMAL-TISSUES (EN)
CARCINOMA (EN)
retrospective study (EN)

EUROPEAN JOURNAL OF DERMATOLOGY (EN)

Αγγλική γλώσσα

JOHN LIBBEY EUROTEXT LTD (EN)




*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.