Add-on lamotrigine treatment and plasma glutamate levels in epilepsy: Relation to treatment response

δείτε την πρωτότυπη σελίδα τεκμηρίου
στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*



Add-on lamotrigine treatment and plasma glutamate levels in epilepsy: Relation to treatment response (EN)

Limpitaki, G (EN)
Triantafyllou, NI (EN)
Petropoulou, O (EN)
Paraskevas, GP (EN)
Kapaki, E (EN)
Vassilopoulos, D (EN)

journalArticle (EN)

2014-03-01T01:55:30Z
2006 (EN)


We investigated the effects of add-on lamotrigine treatment on plasma glutamate (Glu) levels, in 29 epileptic patients. Plasma Glu levels were determined by high-performance liquid chromatography at baseline and at 1 and 3 months post-treatment. In patients with a seizure reduction of >= 66% a decrease of Glu at month 1 was noted, followed by return to baseline levels at month 3. In the remaining patients a gradual increase of Glu was noted throughout the 3 months of the study. The above findings indicate that an excellent clinical response to add-on lamotrigine may be characterized by a statistically significant, yet transient decrease of plasma Glu levels, while increasing Glu levels may accompany a response that is moderate at best. The combination of lamotrigine with valproate was more frequent in patients with excellent clinical response and tended to result in glutamate decrease. (c) 2006 Elsevier B.V All rights reserved. (EN)

Clinical Neurology (EN)

epilepsy (EN)
SERUM AMINO-ACIDS (EN)
METABOLISM (EN)
ASPARTATE (EN)
lamotrigine (EN)
excitatory neurotransmitters (EN)
AMYOTROPHIC-LATERAL-SCLEROSIS (EN)
POLYTHERAPY (EN)
CEREBROSPINAL-FLUID (EN)
ANTIEPILEPTIC DRUG (EN)
glutamate (EN)

EPILEPSY RESEARCH (EN)

Αγγλική γλώσσα

ELSEVIER SCIENCE BV (EN)




*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.